Journal ArticleDOI
Longitudinal Alveolar Bone Loss in Postmenopausal Osteoporotic/Osteopenic Women
TLDR
The data suggest that osteoporosis/osteopenia and estrogen deficiency are risk factors for alveolar bone density loss in postmenopausal women with a history of periodontitis.Abstract:
The purpose of this 2-year longitudinal clinical study was to investigate alveolar (oral) bone height and density changes in osteoporotic/osteopenic women compared with women with normal lumbar spine bone mineral density (BMD) Thirty-eight postmenopausal women completed this study; 21 women had normal BMD of the lumbar spine, while 17 women had osteoporosis or osteopenia of the lumbar spine at baseline All subjects had a history of periodontitis and participated in 3- to 4-month periodontal maintenance programs No subjects were current smokers All patients were within 5 years of menopause at the start of the study Four vertical bitewing radiographs of posterior sextants were taken at baseline and 2-year visits Radiographs were examined using computer-assisted densitometric image analysis (CADIA) for changes in bone density at the crestal and subcrestal regions of interproximal bone Changes in alveolar bone height were also measured Radiographic data were analyzed by the t-test for two independent samples Osteoporotic/osteopenic women exhibited a higher frequency of alveolar bone height loss (p<005) and crestal (p<0025) and subcrestal (p<003) density loss relative to women with normal BMD Estrogen deficiency was associated with increased frequency of alveolar bone crestal density loss in the osteoporotic/osteopenic women and in the overall study population (p<005) These data suggest that osteoporosis/osteopenia and estrogen deficiency are risk factors for alveolar bone density loss in postmenopausal women with a history of periodontitisread more
Citations
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Journal ArticleDOI
Sclerostin antibody treatment causes greater alveolar crest height and bone mass in an ovariectomized rat model of localized periodontitis.
TL;DR: Increased serum osteocalcin and osteoprotegerin, and deceased serum tartrate-resistant acid phosphatase and CTx-1 illustrate the ability of Scl-Ab to increase alveolar bone mass by enhancing bone formation and decreasing bone resorption in an animal model of estrogen deficiency osteopenia plus periodontitis.
Journal ArticleDOI
Tooth loss and osteoporosis: to assess the association between osteoporosis status and tooth number
TL;DR: Clinicians should inform osteoporotic patients they may be at greater risk of tooth loss and instigate more intensive preventive regimens for these individuals.
Journal ArticleDOI
Alveolar bone loss in osteoporosis: a loaded and cellular affair?
Grethe Jonasson,Marianne Rythén +1 more
TL;DR: Hormones, osteoporosis, and aging influence the alveolar process and the skeletal bones similarly, but differences in loading between loaded, half-loaded, and unloaded bones are important to consider.
Journal ArticleDOI
Influence of sex steroids on inflammation and bone metabolism.
TL;DR: Age-associated reductions in sex steroids provide insight into apparent temporal increases in susceptibility to periodontitis and alveolar bone loss, particularly among women.
Journal ArticleDOI
Dental and radiographic findings as predictors of osteoporosis in postmenopausal women.
TL;DR: The relationship between dental findings and osteoporosis in postmenopausal women was evaluated and it was found that dental findings in women diagnosed with premenopausal breast cancer are more likely to be predictive of fractures than those in women without breast cancer.
References
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Journal ArticleDOI
A Long-Term Survey of Tooth Loss in 600 Treated Periodontal Patients
TL;DR: Patients in a private periodontal practice were reexamined an average of 22 years after their active treatment and the patterns of tooth loss were observed and tooth retention seemed more closely related to the case type than the surgery performed.
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Tooth Loss in 100 Treated Patients With Periodontal Disease: A Long-Term Study
TL;DR: periodontal disease appears to be bilaterally symmetrical and tooth loss response emulated this pattern with greatest loss of maxillary second molars and least loss of mandibular cuspids.
Journal ArticleDOI
Race and sex differences in hip fracture incidence.
TL;DR: Analysis based on an independent data source of non-federal hospital discharges in Washington, DC confirmed that White women were at twice the risk for hip fracture compared with Black women and at 2.7 times the risk compared to White men.
Journal ArticleDOI
The Bone Density of Female Twins Discordant for Tobacco Use
John L. Hopper,Ego Seeman +1 more
TL;DR: Whether a deficit in bone density is associated with tobacco use and, if so, to identify the responsible mechanisms is ascertained.
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Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.
Roberto Pacifici,Leonard Rifas,Ruth McCracken,Iris Vered,Cynthia T. McMurtry,Louis V. Avioli,William A. Peck +6 more
TL;DR: The hypothesis is that alterations in IL-1 production may underlie the postmenopausal acceleration in bone loss and its inhibition by ovarian steroids and is based on data from prospective and prospective studies.