Journal ArticleDOI
Loss of diastolic time as a mechanism of exercise-induced diastolic dysfunction in dilated cardiomyopathy
Gunnar Plehn,Julia Vormbrock,Christian Perings,Sebastian Machnick,Christian Zuehlke,Hans-Joachim Trappe,Axel Meissner +6 more
TLDR
An abnormal shortening of diastolic time during exercise can restrict left ventricular filling to an extent that is sufficient to limitleft ventricular stroke volume reserve and to cause pulmonary congestion.About:
This article is published in American Heart Journal.The article was published on 2008-06-01. It has received 20 citations till now. The article focuses on the topics: Idiopathic dilated cardiomyopathy & Diastole.read more
Citations
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Journal ArticleDOI
Optimisation of atrioventricular delay during exercise improves cardiac output in patients stabilised with cardiac resynchronisation therapy
Jing Ping Sun,Alex Pui-Wai Lee,Richard A. Grimm,Ming-Jui Hung,Xing Sheng Yang,David B. Delurgio,Angel R. Leon,John D. Merlino,Cheuk-Man Yu +8 more
TL;DR: Haemodynamically optimal AV delay shortened progressively with increasing heart rate during exercise, which suggests the need for programming of rate-adaptive AV delay in CRT recipients.
Journal ArticleDOI
Rate-adaptive AV delay and exercise performance following cardiac resynchronization therapy
Nesan Shanmugam,Oscar Prada-Delgado,Ana Garcia Campos,Alex Grimster,Oswaldo Valencia,Aigul Baltabaeva,Susan Jones,Lisa J. Anderson +7 more
TL;DR: There was a dramatic reduction in optimal AV delay with physiological exercise in the majority of this heart failure cardiac resynchronization therapy cohort and replicating this physiological response with a programmable RAAVD translated into a 10% improvement in exercise capacity.
Journal ArticleDOI
Echocardiography-Guided Biventricular Pacemaker Optimization
TL;DR: Studies in echo-guided pacemaker optimization are discussed, a systemic guide to pacemaker interrogation and optimization in patients after Biv pacing who may have complex hemodynamic derangement is provided, and studies in optimization with exercise or atrial pacing are discussed.
Journal ArticleDOI
Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children With Idiopathic or Familial Dilated Cardiomyopathy
Tapas Mondal,Cameron Slorach,Cedric Manlhiot,Wei Hui,Paul F. Kantor,Brian W. McCrindle,Luc Mertens,Mark K. Friedberg +7 more
TL;DR: A high S:D ratio is associated with increased risk for death or need for transplant in children withDCM across the spectrum of heart rates and may be a useful prognostic index for serial evaluation of children with DCM.
Journal ArticleDOI
Cardiac mechanisms underlying normal exercise tolerance: gender impact
TL;DR: Normal exercise capacity as determined by pVO2 is related to the indexed stroke volume in males and left atrial pressure in females, which may explain the known vulnerability of women to endurance exercise compared to men.
References
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Journal ArticleDOI
Regulation of stroke volume during submaximal and maximal upright exercise in normal man.
TL;DR: The mechanism by which left ventricular stroke volume increases during upright exercise in man is dependent upon the changing relationship between heart rate,Left ventricular filling, and left vent cardiac contractility, and endsystolic volume index.
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Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration
Stefano Ghio,Cristina Constantin,Catherine Klersy,Alessandra Serio,Alessandra Fontana,Carlo Campana,Luigi Tavazzi +6 more
TL;DR: A substantial proportion of heart failure patients with a slightly prolonged QRS or even with normal conduction may exhibit ventricular dyssynchrony, and both standard echocardiography and tissue Doppler imaging are necessary to describe the entire spectrum of mechanical abnormalities due to dyss synchrony.
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Effect of left bundle branch block on diastolic function in dilated cardiomyopathy.
H B Xiao,C H Lee,Derek G. Gibson +2 more
TL;DR: Left bundle branch block prolongs rather than delays mitral regurgitation by increasing pre-ejection and relaxation times, which directly impairs diastolic function by shortening the time available for the left ventricule to fill to an extent likely to limit stroke volume.
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Determinants of Duration and Mean Rate of Ventricular Ejection
TL;DR: The independent influences of stroke volume, heart rate, aortic pressure, hypothermia, sympathomimetic amines, metered mitral and aortIC valvular regurgitation, and alterations in myocardial contractility on the duration and mean rate of ventricular ejection and filling were studied.
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Duration of diastole and its phases as a function of heart rate during supine bicycle exercise
TL;DR: It is concluded that the elimination of diastasis and merging of E and A waves of nearly fixed durations primarily govern changes in MDD, supporting the perspective that E- and A-wave durations are primarily governed by the rules of mechanical oscillation that are minimally HR dependent.