Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study.
Elizabeth Barrett-Connor,Judith E. Mueller,Denise von Mühlen,Gail A. Laughlin,Diane L. Schneider,David J. Sartoris +5 more
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TLDR
The data suggest that estrogen plays a critical role in the skeletal health of older men and confirm other studies showing no association of postmenopausal endogenous estrogen levels with vertebral fractures in older women.Abstract:
This longitudinal study included 288 postmenopausal women without estrogen use (median age, 72 yr) and 352 men (median age, 66 yr). All were community-dwelling, ambulatory, and Caucasian. Blood for hormone assays (total and bioavailable estradiol and testosterone, estrone, androstenedione, dihydrotestosterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate) was obtained in 1984–1987, and vertebral fractures were diagnosed from lateral spine radiographs obtained in 1992–1996. At least one vertebral fracture was found in 21% of women and 8% of men. Among men, age-adjusted hormone levels differed by fracture status only for total (64.1 vs. 75.4 pmol/L, P = 0.012) and bioavailable (43.0 vs. 51.4 pmol/L, P = 0.008) estradiol. There was a graded association between higher concentrations of total and bioavailable estradiol and lower fracture prevalence (trend P < 0.01 for both hormones). Men with total testosterone levels compatible with hypogonadism (<7 nmol/L) were not more likely to have vertebral...read more
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The decline of androgen levels in elderly men and its clinical and therapeutic implications.
Jean Kaufman,Alex Vermeulen +1 more
TL;DR: Until the long-term risk-benefit ratio for androgen administration to elderly is established in adequately powered trials of longer duration, androgen administrations to elderly men should be reserved for the minority of elderly men who have both clear clinical symptoms of hypogonadism and frankly low serum testosterone levels.
Journal ArticleDOI
Andropause Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men
TL;DR: From a practical clinical standpoint, it is most appropriate to define “andropause” as an age-related decline in serum T levels in older men to below the normal range in young men that is associated with a clinical syndrome consistent with androgen deficiency.
Journal ArticleDOI
Estradiol in elderly men
TL;DR: The role of estrogens in male physiology has become more evident, as a consequence of the discovery of human models of estrogen deficiency such as estrogen resistance or aromatase deficiency, and plasma testosterone is a major determinant.
Journal ArticleDOI
Effect of puberty on body composition
TL;DR: The effect of puberty on components of human body composition, including adiposity (total body fat, percentage body fat and fat distribution), lean body mass and bone mineral content and density is examined.
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Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden.
Dan Mellström,Olof Johnell,Östen Ljunggren,Anna Eriksson,Mattias Lorentzon,Hans Mallmin,Anna Holmberg,Inga Redlund-Johnell,Eric S. Orwoll,Claes Ohlsson +9 more
TL;DR: It is shown that free testosterone within the normal range is a predictor of BMD at predominantly cortical bone sites and of previous osteoporosis‐related fractures in elderly Swedish men.
References
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Journal ArticleDOI
Vertebral fracture assessment using a semiquantitative technique
TL;DR: The semiquantitative approach can be applied reliably in vertebral fracture assessment when performed using well‐defined criteria, and this approach was compared with a quantitative morpho‐metric approach.
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Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Eric P. Smith,Jeff Boyd,Graeme R. Frank,Hiroyuki Takahashi,Robert M. Cohen,Bonny Specker,Timothy C. Williams,Dennis B. Lubahn,Kenneth S. Korach +8 more
TL;DR: Disruption of the estrogen receptor in humans need not be lethal and is important for bone maturation and mineralization in men as well as women.
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Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
TL;DR: A novel mutation in the CYP19 gene in a sister and brother exhibited the cardinal features of the aromatase deficiency syndrome as recently defined and was reported on.
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Evidence of estrogen receptors in normal human osteoblast-like cells
Erik Fink Eriksen,D. S. Colvard,D. S. Colvard,N. J. Berg,N. J. Berg,Mark L. Graham,Mark L. Graham,Kenneth G. Mann,Thomas C. Spelsberg,Thomas C. Spelsberg,B L Riggs,B L Riggs +11 more
TL;DR: The data suggest that estrogen acts directly on human bone cells through a classical estrogen receptor-mediated mechanism, indicating an induction of functional progesterone receptors.
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A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men
TL;DR: A new unitary model for the pathophysiology of involutional osteoporosis is proposed that identifies estrogen (E) deficiency as the cause of both the early, accelerated and the late, slow phases of bone loss in postmenopausal women and as a contributing cause of the continuous phase ofBone loss in aging men.