Low morbidity and mortality of status epilepticus in children
TLDR
The mortality and incidence of sequelae following status epilepticus was low and primarily a function of etiology, and age did not affect outcome within each cause.Abstract:
In an ongoing study of status epilepticus, 193 children with status epilepticus of varying causes have been followed up for a mean period of 132 months Of these, 97 patients were recruited prospectively The patients' ages ranged from 1 month to 18 years (mean, 50 years) The cause of the status epilepticus was classified as idiopathic in 46 cases, remote symptomatic in 45, febrile in 46, acute symptomatic in 45, and progressive neurologic in 11 The mortality and incidence of sequelae following status epilepticus was low and primarily a function of etiology Seven children died within 3 months of having the seizure New neurologic deficits were found in 17 (91%) of the 186 survivors All of the deaths and 15 of the 17 sequelae occurred in the 56 children with acute or progressive neurologic insults Only two of the 137 children with other causes sustained any new deficits (P less than 001) Duration of the status epilepticus affected outcome only within the acute symptomatic group (P less than 05) Neurologic sequelae occurred in 29% of infants younger than 1 year of age, 11% of children 1 to 3 years of age, and 6% of children older than 3 years of age However, this was a reflection of the greater incidence of acute neurologic disease in the younger age groups Within each cause, age did not affect outcome Of the 193 children, 61 (32%) had a history of prior unprovoked seizures Of the 125 surviving children with no history of prior unprovoked seizures, 37 (30%) had subsequent unprovoked seizures(ABSTRACT TRUNCATED AT 250 WORDS)read more
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Guidelines for the Evaluation and Management of Status Epilepticus
Gretchen M. Brophy,Rodney Bell,Jan Claassen,Brian K. Alldredge,Thomas P. Bleck,Tracy A. Glauser,Suzette M. LaRoche,James J. Riviello,Lori Shutter,Michael R. Sperling,David M. Treiman,Paul M. Vespa +11 more
TL;DR: Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.
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Neonatal brain injury.
TL;DR: Recognition of at-risk newborns by means of advanced methods of neuroimaging, combined with a plan for rational intervention, may result in the prevention or the reduction in the incidence of lifelong disabilities such as cerebral palsy, epilepsy, and behavioral and learning disorders.
Journal ArticleDOI
A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia
Robert J. DeLorenzo,W. A. Hauser,Alan R. Towne,J. G. Boggs,John M. Pellock,L. Penberthy,L.K. Garnett,C. A. Fortner,Daijin Ko +8 more
TL;DR: Evaluation of the seizure types for adult and pediatric patients demonstrated that both partial and generalized status epilepticus occur with a high frequency in these populations.
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Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society
Tracy A. Glauser,Shlomo Shinnar,David Gloss,Brian K. Alldredge,Ravindra Arya,Jacquelyn L. Bainbridge,Mary A Bare,Thomas P. Bleck,W. Edwin Dodson,Lisa Garrity,Andy Jagoda,Daniel H. Lowenstein,John M. Pellock,James Riviello,Edward P. Sloan,David M. Treiman +15 more
TL;DR: Despite the paucity of well-designed randomized controlled trials, practical conclusions and an integrated treatment algorithm for the treatment of convulsive status epilepticus across the age spectrum (infants through adults) can be constructed.
Journal ArticleDOI
Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy.
TL;DR: All of the pathophysiological changes induced by perforant path stimulation were replicated in normal animals by a subconvulsive dose of bicuculline, suggesting that the permanent “epileptiform” abnormalities produced by sustained perforan path stimulation may be due to decreased GABA‐mediated inhibition.