Journal ArticleDOI
Low serum magnesium levels and metabolic syndrome.
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TLDR
A cross-sectional population-based study reveals a strong relationship between decreased serum magnesium and MS and among the components of MS, dyslipidemia and HBP were strongly related to low serum magnesium levels.Abstract:
Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). We performed a cross-sectional population-based study to compare 192 individuals with MS and 384 disorder-free control subjects, matched by age and gender. Magnesium supplementation treatment and conditions likely to provoke hypomagnesemia, including previous diagnosis of diabetes mellitus (DM) and/or high blood pressure (HBP), were exclusion criteria. In this regard, only incident cases of DM and HBP were included. MS was defined by the presence at least of two of the following features: hyperglycemia (≥7.0 mmol/l); HBP (≥160/90 mmHg); dyslipidemia (fasting triglycerides ≥1.7 mmol/l and/or HDLcholesterol <1.0 mmol/l); and obesity (body mass index ≥30 kg/m2 and/or waist-to-hip ratio ≥0.85 in women or ≥0.9 in men). Low serum magnesium levels were identified in 126 (65.6%) and 19 (4.9%) individuals with and without MS, p<0.00001. The mean serum magnesium level among subjects with MS was 1.8±0.3 mg/dl, and among control subjects 2.2±0.2 mg/dl, p<0.00001. There was a strong independent relationship between low serum magnesium levels and MS (odds ratio (OR)=6.8, CI95% 4.2–10.9). Among the components of MS, dyslipidemia (OR 2.8, CI95% 1.3–2.9) and HBP (OR 1.9, CI95% 1.4–2.8) were strongly related to low serum magnesium levels. This study reveals a strong relationship between decreased serum magnesium and MS.read more
Citations
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Journal ArticleDOI
Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come
Rebecca B. Costello,Ronald J. Elin,Andrea Rosanoff,Taylor C. Wallace,Fernando Guerrero-Romero,Adela Hruby,Pamela L. Lutsey,Forrest H. Nielsen,Martha Rodríguez-Morán,Yiqing Song,Linda Van Horn +10 more
TL;DR: Data is presented from an array of scientific studies to support the perspective that subclinical deficiencies in magnesium exist, that they contribute to several chronic diseases, and that adopting a revised serum magnesium reference interval would improve clinical care and public health.
Journal ArticleDOI
Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation.
S. Van Laecke,W. Van Biesen,Francis Verbeke,Dirk De Bacquer,Patrick Peeters,Raymond Vanholder +5 more
TL;DR: The relationship between hypomagnesemia, NODAT and the type of immunosuppression in renal transplant recipients is examined in patients with new‐onset diabetes after transplantation.
Journal ArticleDOI
High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation.
TL;DR: Experimental evidence is discussed showing that the metabolic syndrome, high fructose intake and low magnesium diet may all be linked to the inflammatory response, and the expected consequence would be an increased risk of developing insulin resistance when magnesium deficiency is combined with a high-fructose diet.
Journal ArticleDOI
Magnesium in disease.
Helmut Geiger,Christoph Wanner +1 more
TL;DR: Magnesium sulphate as an intravenous infusion also has an important established therapeutic role in pregnant women with pre-eclampsia as it decreases the risk of eclamptic seizures by half compared with placebo.
Journal ArticleDOI
Consumption of Whole-Grain Cereals during Weight Loss: Effects on Dietary Quality, Dietary Fiber, Magnesium, Vitamin B-6, and Obesity
Kathleen J. Melanson,Theodore J. Angelopoulos,Von Nguyen,Margaret C. Martini,Linda Zukley,Joshua Lowndes,Thomas J. Dube,Justin J. Fiutem,Byron W. Yount,James M. Rippe +9 more
TL;DR: Weight-reduction strategies may be associated with reduced intake of micronutrients, such as calcium and vitamin E, however, a hypocaloric diet with fiber-rich whole-grain cereal is effective for improving or maintaining other aspects of dietary quality during weight loss.
References
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Journal ArticleDOI
Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study
TL;DR: That low dietary magnesium intake does not confer risk for type 2 diabetes implies that compartmentalization and renal handling of magnesium may be important in the relationship between low serum magnesium levels and the risk forType 2 diabetes.
Journal ArticleDOI
Magnesium metabolism in health and disease
TL;DR: There is no readily available test to determine intracellular/total body magnesium status and the clinical laboratory evaluation of magnesium status is primarily limited to the serum magnesium concentration, 24-hour urinary excretion, and percent retention following parenteral magnesium.