Journal ArticleDOI
Low serum magnesium levels and metabolic syndrome.
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A cross-sectional population-based study reveals a strong relationship between decreased serum magnesium and MS and among the components of MS, dyslipidemia and HBP were strongly related to low serum magnesium levels.Abstract:
Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). We performed a cross-sectional population-based study to compare 192 individuals with MS and 384 disorder-free control subjects, matched by age and gender. Magnesium supplementation treatment and conditions likely to provoke hypomagnesemia, including previous diagnosis of diabetes mellitus (DM) and/or high blood pressure (HBP), were exclusion criteria. In this regard, only incident cases of DM and HBP were included. MS was defined by the presence at least of two of the following features: hyperglycemia (≥7.0 mmol/l); HBP (≥160/90 mmHg); dyslipidemia (fasting triglycerides ≥1.7 mmol/l and/or HDLcholesterol <1.0 mmol/l); and obesity (body mass index ≥30 kg/m2 and/or waist-to-hip ratio ≥0.85 in women or ≥0.9 in men). Low serum magnesium levels were identified in 126 (65.6%) and 19 (4.9%) individuals with and without MS, p<0.00001. The mean serum magnesium level among subjects with MS was 1.8±0.3 mg/dl, and among control subjects 2.2±0.2 mg/dl, p<0.00001. There was a strong independent relationship between low serum magnesium levels and MS (odds ratio (OR)=6.8, CI95% 4.2–10.9). Among the components of MS, dyslipidemia (OR 2.8, CI95% 1.3–2.9) and HBP (OR 1.9, CI95% 1.4–2.8) were strongly related to low serum magnesium levels. This study reveals a strong relationship between decreased serum magnesium and MS.read more
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Journal ArticleDOI
Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders
Tsuyoshi Honda,Koichi Kaikita,Kenichi Tsujita,Takanori Hayasaki,Masakazu Matsukawa,Shunichiro Fuchigami,Seigo Sugiyama,Naomi Sakashita,Hisao Ogawa,Motohiro Takeya +9 more
TL;DR: It is suggested that metabolic disorders exacerbate ischemia-reperfusion injury as a result of overexpression of inflammatory mediators, and this effect might be improved, in part by the anti-inflammatory effects of pioglitazone.
Journal ArticleDOI
Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects ☆
TL;DR: The results show that hypomagnesemia is positively associated with the presence of MONW phenotype, and the normomagneemia negatively with the MHO phenotype.
Journal ArticleDOI
Serum magnesium and type-2 diabetes in African Americans and Hispanics: a New York cohort.
Earle C. Chambers,Stanley Heshka,Dympna Gallagher,Jack Wang,F. Xavier Pi-Sunyer,Richard N. Pierson +5 more
TL;DR: Results show that in African American and Hispanic adults, those with diabetes have lower serum Mg levels compared to those classified as pre-diabetic or those with normal fasting glucose levels.
Journal ArticleDOI
Magnesium intake and prevalence of metabolic syndrome in adults: Tehran Lipid and Glucose Study.
Parvin Mirmiran,Sakineh Shab-Bidar,Firoozeh Hosseini-Esfahani,Golaleh Asghari,Somayeh Hosseinpour-Niazi,Fereidoun Azizi +5 more
TL;DR: A significant inverse association between dietary Mg, MetS and its components is suggested and this association was attenuated following further adjustment for dietary factors and menopausal status.
Journal ArticleDOI
Magnesium Replacement Does Not Improve Insulin Resistance in Patients With Metabolic Syndrome: A 12-Week Randomized Double-Blind Study
Maria de Lourdes Lima de Souza e Silva,Thomaz Cruz,Luiz Erlon Araújo Rodrigues,Ana Marice Teixeira Ladeia,Olivia Bomfim,Lucas Olivieri,Juliana Melo,Raquel Correia,Mirna Porto,Alexandre Cedro +9 more
TL;DR: Serum and intracellular Mg depletion is common in patients with MS; however, Mg replacement in recommended dosage did not increase significantly Mg levels, neither reduced insulin resistance or metabolic control.
References
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Journal ArticleDOI
Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study
TL;DR: That low dietary magnesium intake does not confer risk for type 2 diabetes implies that compartmentalization and renal handling of magnesium may be important in the relationship between low serum magnesium levels and the risk forType 2 diabetes.
Journal ArticleDOI
Magnesium metabolism in health and disease
TL;DR: There is no readily available test to determine intracellular/total body magnesium status and the clinical laboratory evaluation of magnesium status is primarily limited to the serum magnesium concentration, 24-hour urinary excretion, and percent retention following parenteral magnesium.