Journal ArticleDOI
Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer.
Donald C. McMillan,Maqsood M. Elahi,Naveed Sattar,Wilson J. Angerson,Jennie Johnstone,Colin S. McArdle +5 more
TLDR
It is indicated that in advanced cancer patients the presence of a systemic inflammatory response and the magnitude of that response predict the duration of cancer-specific and non-cancer survival.Abstract:
The assessment of prognosis in patients with advanced cancer remains problematical. The value of C-reactive protein concentration in this context has not been clearly defined. Patients with a diagnosis of colorectal (n = 182), gastric (n = 87), breast (n = 99), or bronchogenic (n = 404) cancer and who had measurements of C-reactive protein and albumin were identified. Median survival, from the time of sampling, ranged from 478 days in the colorectal cancer patients to 60 days in patients with bronchogenic cancer. On univariate analysis, there was, in each tumor type, a significant relationship between the duration of survival and both log10 C-reactive protein and albumin concentrations (P ? 0.0002). On multivariate analysis, in each tumor type, log10 C-reactive protein remained a significant independent predictor of survival (P ? 0.0002). When all four groups of cancer patients were analyzed (n = 772), the hazard ratio for a 10-fold increase in C-reactive protein concentration in cancer-specific survival ...read more
Citations
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The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer.
TL;DR: The GPS/mGPS is the most extensively validated of the systemic inflammation-based prognostic scores and therefore may be used in the routine clinical assessment of patients with cancer and provides a well defined therapeutic target for future clinical trials.
Journal ArticleDOI
Prognostic factors in advanced cancer patients: evidence-based clinical recommendations--a study by the Steering Committee of the European Association for Palliative Care.
Marco Maltoni,Augusto Caraceni,Cinzia Brunelli,Bert Broeckaert,Nicholas A. Christakis,Steffen Eychmueller,Paul Glare,Maria Nabal,Antonio Vigano,Philip Larkin,Franco De Conno,Geoffrey Hanks,Stein Kaasa +12 more
TL;DR: Evidence-based recommendations of prognostic correlation could be formulated for CPS (albeit with a series of limitations of which clinicians must be aware) and prognostic scores and more accurate prognostication is feasible and can be achieved by combining clinical experience and evidence from the literature.
Journal ArticleDOI
Systemic inflammatory response predicts survival following curative resection of colorectal cancer.
TL;DR: The aim of this study was to examine the relationship between the inflammatory response and overall and cancer‐specific survival in patients undergoing potentially curative resection for colorectal cancer.
Journal ArticleDOI
Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer
TL;DR: Elevated levels of CRP in cancer-free individuals are associated with increased risk of cancer of any type, of lung cancer, and possibly of colorectal cancer, particularly in patients without metastases.
Journal ArticleDOI
An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer.
TL;DR: The Glasgow prognostic score (GPS) as mentioned in this paper is derived from the acute phase proteins C-reactive protein and albumin and is termed the Glasgow prognosis score (gPS).
References
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Journal ArticleDOI
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Cem Gabay,Irving Kushner +1 more
TL;DR: A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation, and the mechanisms mediating them are becoming better understood.
Journal ArticleDOI
C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men Results From the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992
Wolfgang Koenig,M. Sund,Margit Fröhlich,Hans-Günther Fischer,Hannelore Löwel,Angela Döring,Winston L. Hutchinson,Mark B. Pepys +7 more
TL;DR: These results confirm the prognostic relevance of CRP, a sensitive systemic marker of inflammation, to the risk of CHD in a large, randomly selected cohort of initially healthy middle-aged men and suggest that low-grade inflammation is involved in pathogenesis of atherosclerosis, especially its thrombo-occlusive complications.
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Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study.
TL;DR: Doctors are inaccurate in their prognoses for terminally ill patients and the error is systematically optimistic, which may be adversely affecting the quality of care given to patients near the end of life.
Journal ArticleDOI
Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer
TL;DR: A preoperative serum elevation of CRP was found to be an indicator of the malignant potential of the tumor as well as a predictor of the prognosis of patients with colorectal cancer.
Journal ArticleDOI
Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer.
Fancisco Martı́n,Francisco Santolaria,Norberto Batista,Antonio Milena,Emilio González-Reimers,Marı́a J. Brito,Juana Oramas +6 more
TL;DR: IL-6 is increased in lung cancer patients, enhances the acute phase response in them, and is correlated with poor nutritional status, impaired performance status and shorter survival.