Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors.
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TLDR
The discovery that pentosidine can form not only from pentoses but also from hexoses and ascorbate raises major new questions concerning biochemical pathways of the Maillard reaction in vivo.About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-06-25 and is currently open access. It has received 465 citations till now. The article focuses on the topics: Pentosidine & Maillard reaction.read more
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Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.
TL;DR: It is evident that the cyclic oxidation and reduction of the sulfur-containing amino acids may serve as an important antioxidant mechanism, and also that these reversible oxidations may provide an important mechanism for the regulation of some enzyme functions.
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Activation of Receptor for Advanced Glycation End Products: A Mechanism for Chronic Vascular Dysfunction in Diabetic Vasculopathy and Atherosclerosis
TL;DR: In a model of accelerated atherosclerosis associated with diabetes in genetically manipulated mice, blockade of cell surface RAGE by infusion of a soluble, truncated form of the receptor completely suppressed enhanced formation of vascular lesions, suggesting that interaction of cellular RAGE with its ligands could be a factor contributing to a range of important chronic disorders.
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Advanced Maillard reaction end products are associated with Alzheimer disease pathology
Mark A. Smith,Shinji Taneda,P. L. Richey,Satoshi Miyata,Shi Du Yan,David M. Stern,Lawrence M. Sayre,Vincent M. Monnier,George Perry +8 more
TL;DR: In this article, the authors present evidence that the characteristic pathological structures associated with Alzheimer disease contain modifications typical of advanced Maillard reaction end products, which are initiated by the condensation between amino groups of proteins and reducing sugars.
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Accumulation of Maillard reaction products in skin collagen in diabetes and aging
Daniel G. Dyer,John A. Dunn,Suzanne R. Thorpe,Karen E. Bailie,Timothy L. Lyons,David R. McCance,John W. Baynes +6 more
TL;DR: The contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes was investigated in this paper, where the Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 non-diabetic control subjects.
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Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.
Theodore Koschinsky,Cijiang He,Tomoko Mitsuhashi,Richard Bucala,Cecilia Liu,Christina Buenting,Kirsten Heitmann,Helen Vlassara +7 more
TL;DR: The renal excretion of orally absorbed AGEs is markedly suppressed in diabetic nephropathy patients, daily influx of dietary A GEs includes glycotoxins that may constitute an added chronic risk for renal-vascular injury in DM, and dietary restriction of AGE food intake may greatly reduce the burden of AAGEs in diabetic patients and possibly improve prognosis.
References
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Rapid chromatographic technique for preparative separations with moderate resolution
Abstract: (11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).
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Method for the determination of hexosamines in tissues.
TL;DR: During the course of investigations on the metabolism of hexosamines in animal tissues, absorption spectra of the color produced in the hexosamine method of Elson and Morgan revealed the presence of interfering chromogens.
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Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes.
Simon P. Wolff,Roger T. Dean +1 more
TL;DR: It is suggested that a component of protein glycosylation is dependent upon glucose autoxidation and subsequent covalent attachment of ketoaldehydes, and the chemical evidence for the currently accepted 'Amadori' product is consistent with the structure expected for the attachment of a glucose-derived ketoaldehyde to protein.
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Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix: Implication of Pentoses in the Aging Process *
David R. Sell,Vincent M. Monnier +1 more
TL;DR: The unexpected discovery of pentose-mediated protein cross-linking raises new questions concerning the aging process and suggests ribose or ribonucleotide metabolites as precursors.
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Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix: Implication of Pentoses in the Aging Process *
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