Journal ArticleDOI
Mechanism of placebo analgesia
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This article is published in The Lancet.The article was published on 1978-12-16. It has received 266 citations till now.read more
Citations
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Journal ArticleDOI
Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale
TL;DR: The absolute type of VAS seems to be less sensitive to bias than the comparative one and is therefore preferable for general clinical use and should be paid to several complementary indices of pain relief as well as to the individual's tendency to bias his estimates.
Journal ArticleDOI
Biological, clinical, and ethical advances of placebo effects
TL;DR: Promotion and integration of laboratory and clinical research will allow advances in the ethical use of placebo mechanisms that are inherent in routine clinical care, and encourage the use of treatments that stimulate placebo effects.
Journal ArticleDOI
Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems
TL;DR: The findings show that cognitive factors and conditioning are balanced in different ways in placebo analgesia, and this balance is crucial for the activation of opioid or nonopioid systems.
Journal ArticleDOI
State-dependent opioid control of pain
TL;DR: There is growing evidence that the state of the circuit is determined by aversive and appetitive motivational states, and that this contributes to adaptive behavioural choice.
Journal ArticleDOI
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Falk Eippert,Ulrike Bingel,Eszter D. Schoell,Juliana Yacubian,Regine Klinger,Jürgen Lorenz,Christian Büchel +6 more
TL;DR: Findings show that opioidergic signaling in pain-modulating areas and the projections to downstream effectors of the descending pain control system are crucially important for placebo analgesia.
References
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Journal ArticleDOI
A study of the placebo response
TL;DR: A group of 162 postoperative patients was observed for the ability of such patients to receive significant relief of pain from subcutaneous injections of placebo and of morphine and a hypothesis to explain the placebo response is postulated.
Journal ArticleDOI
Deoxyribonucleic Acid Antibody: A Method to Detect Its Primary Interaction with Deoxyribonucleic Acid
TL;DR: This sensitive and specific technique, which measures the primary interaction between DNA and antibody to DNA, is based on the observation that free DNA is soluble in 50-percent saturated ammonium sulfate whereas antibody-bound DNA is insoluble.
Journal ArticleDOI
Malignant histiocytosis (histiocytic medullary reticulosis). I. Clinicopathologic study of 29 cases
TL;DR: The clinical records and histologic materials from 29 cases of malignant histiocytosis have been reviewed, as well as autopsy findings in 14 cases, and bone marrow aspiration was superior to biopsy in assessing marrow involvement.
Journal ArticleDOI
The narcotic antagonist naloxone enhances clinical pain
TL;DR: It is demonstrated here that following the extraction of impacted wisdom teeth, naloxone causes a significantly greater increase in reported pain intensity than placebo, an observation consistent with the suggested participation of endorphins in an intrinsic pain suppression system.
Related Papers (5)
The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia.
Influence of the method of drug administration on analgesic response
Jon D. Levine,Newton C. Gordon +1 more