Journal ArticleDOI
"Medical oophorectomy" using a long-acting GNRH agonist--a possible new approach to the treatment of endometriosis.
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TLDR
Five women with endometriosis were given a daily dose of a potent long-acting GnRH agonist, D-Trp6-Pro9-Net-LHRH (GnRH-A) for 28 days in an attempt to suppress ovarian estrogen secretion, suggesting differing intracellular control mechanisms for release of the two gonadotropins.Abstract:
Five women with endometriosis were given a daily dose of a potent long-acting GnRH agonist, D-Trp6-Pro9-Net-LHRH (GnRH-A) for 28 days in an attempt to suppress ovarian estrogen secretion. The mean level of estradiol (E2) during sampling over 24 hours decreased (P less than 0.01) from 62 +/- 11 to 10 +/- 1 pg/ml at the end of treatment. Mean concentrations of androstenedione, testosterone, estrone and E2 on day 28 of therapy were similar to those measured in oophorectomized women. The level of FSH was decreased (P less than 0.001) during GnRH-a, whereas that of LH was significantly (P less than 0.001) increased, suggesting differing intracellular control mechanisms for release of the two gonadotropins. Desensitization of the pituitary was demonstrated at the end of treatment by a complete lack of acute response of FSH or LH to the daily dose of GnRH-a. "Medical oophorectomy" provides a new approach to the treatment of endometriosis.read more
Citations
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Journal ArticleDOI
Gonadotropin-releasing hormone and its analogues.
Conn Pm,William F. Crowley +1 more
TL;DR: The Food and Drug Administration approvals of GnRH-agonist analogues for the treatment of prostate cancer, endometriosis, and precocious puberty, as well as the use of natural GnRH to induce ovulation, are examples of the clinical usefulness of these fundamental observations.
Journal ArticleDOI
Gonadotropin-releasing hormone and its analogs
Conn Pm,William F. Crowley +1 more
TL;DR: The physiologic and pharmacologic principles underlying the advances produced by these agents, the mechanism of action of GnRH and its analogues at the cellular level, and the individual therapeutic applications to which these analogues have been applied are examined.
Journal ArticleDOI
One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate.
TL;DR: Results indicate that depot formulations of leuprorelin may be potentially useful in the therapy of endocrine diseases in humans and animals.
Journal ArticleDOI
Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial.
Milan R. Henzl,Stephen L. Corson,Kamran Moghissi,Veasy C. Buttram,Christer Berqvist,Jan J. Jacobson +5 more
TL;DR: It is concluded that nafarelin is an effective agent for treating endometriosis and has few side effects other than hypoestrogenism.
References
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Pulsatile patterns of gonadotropin release in subjects with and without ovarian function.
TL;DR: Minute-to-minute fluctuations of serum LH and FSH concentrations resembling a pulsatile pattern were demonstrated in both pre- and post-menopausal women, and a greater net increase of circulating LH was found in pulses during the midcycle surge which was more than double that seen during other phases of the cycle.
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Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivo.
TL;DR: Results suggest that FSH administered in vivo may act on granulosa cells to induce or activate receptors for I_H (hCG) and 3β-hydroxysteroid dehydrogenase activity as well as stimulate follicle-stimulating hormone in ovarian development.
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Circulating gonadotropins, estrogens, and androgens in polycystic ovarian disease.
TL;DR: Serum gonadotropin, estrogen, and androgen levels were measured in samples obtained from 19 patients with polycystic ovarian disease (PCO) and from 10 normal women on day 2 to 4 of their menstrual cycles to show a distinct profile of gonadotropic levels.
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Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis.
TL;DR: Results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.
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Estradiol-17beta biosynthesis in cultured granulosa cells from hypophysectomized immature rats; stimulation by follicle-stimulating hormone.
TL;DR: It is concluded that FSH regulates estrogen biosynthesis in granulosa cells of hypophysectomized rats by a specific stimulation of the aromatizing enzyme system.