Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.
Juliana Félix-Silva,Arnóbio Antônio da Silva-Júnior,Silvana Maria Zucolotto,Matheus F. Fernandes-Pedrosa +3 more
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TLDR
The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.Abstract:
Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.read more
Citations
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Perspective on the Therapeutics of Anti-Snake Venom
TL;DR: Specific therapeutic snakebite envenomation treatments are described and an increased number of literature reports on the ability of natural sources, particularly plants, to treat snakebites are covered, along with their mechanisms, drawbacks and future perspectives.
Journal ArticleDOI
Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia.
TL;DR: Jazan flora has good ethnobotanical potential, and the high-FL species are the most promising candidate plants for in-depth pharmacological screening and merit further consideration.
Journal ArticleDOI
Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology
Júlia Morais Fernandes,Lorena M. Cunha,Eduardo Pereira de Azevedo,Estela M G Lourenço,Matheus F. Fernandes-Pedrosa,Silvana Maria Zucolotto +5 more
TL;DR: This review aims to provide an update overview about the traditional uses, chemical constitution, pharmacology and toxicology of K. laciniata and B. pinnatum species, which have been traditionally used to treat inflammation, microbial infection, pain, respiratory diseases, gastritis, ulcers, diabetes and cancer tumors.
Journal ArticleDOI
Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process.
TL;DR: It is demonstrated that herbal mixture can promote the migration of keratinocytes, fibroblasts, and endothelial cells, and the proliferation of macrophages and lymphatic vessels, and accelerates wound healing, and suggested that herbal mixture may have a potential for therapeutic use for treatment and management of cutaneous wound.
References
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The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths.
Anuradhani Kasturiratne,A. Rajitha Wickremasinghe,Nilanthi de Silva,N. Kithsiri Gunawardena,Arunasalam Pathmeswaran,Ranjan Premaratna,Lorenzo Savioli,David G. Lalloo,H. Janaka de Silva +8 more
TL;DR: It is estimated that, globally, at least 421,000 envenomings and 20,000 deaths occur each year due to snakebite, with the highest burden exists in South Asia, Southeast Asia, and sub-Saharan Africa.
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Survey of medicinal plants used in the region Northeast of Brazil
Maria de Fátima Agra,Kiriaki Nurit Silva,Ionaldo José Lima Diniz Basílio,Patrícia França de Freitas,José Maria Barbosa-Filho +4 more
TL;DR: A survey of the species of plants and their uses as medicinal, which are utilized for therapeutic purposes in Northeast region of Brazil, and the greatest importance of investigation of those species that have not been subject of pharmacological study is emphasized.
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Snake Envenoming: A Disease of Poverty
TL;DR: This study unequivocally demonstrates that snake envenoming is a disease of the poor, and the negative association between snakebite deaths and government expenditure on health confirms that the burden of mortality is highest in those countries least able to deal with the considerable financial cost of snakebite.
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Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India.
TL;DR: Protective activity of plants-Aristolochia indica, Hemidesmus indicus, Gloriosa superba, Strychnos nux-vomica, Eclipta prostrata, and Andrographis paniculata against the lethal action of snake venom and need further investigation.