Journal ArticleDOI
Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory traffic.
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TLDR
This work generated phosphorylation mutants of p115 and tested their ability to target to ER exit sites, ERGIC and the Golgi, and whether expression of the mutants causes disruption of Golgi structure and perturbs ER-Golgi traffic of a VSV-G cargo protein.About:
This article is published in European Journal of Cell Biology.The article was published on 2003-08-01. It has received 10 citations till now. The article focuses on the topics: Golgi apparatus & Golgi reassembly.read more
Citations
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Journal ArticleDOI
Molecular basis for Golgi maintenance and biogenesis.
TL;DR: This work categorizes the expanding list of Golgi-associated proteins on the basis of their role in Golgi reformation after the Golgi has been disassembled to provide important insights for understanding the GolGI's global functions within cells.
Journal ArticleDOI
Golgi tethering factors.
TL;DR: This review of vesicle tethering events at the Golgi complex is described with the understanding that similar events occur during transport via larger structures.
Journal ArticleDOI
p115 Interacts with the GLUT4 Vesicle Protein, IRAP, and Plays a Critical Role in Insulin-stimulated GLUT4 Translocation
Toshio Hosaka,Cydney C. Brooks,Eleonora Presman,Suk-Kyeong Kim,Zidong Zhang,Michael R. Breen,Danielle N. Gross,Elizabeth Sztul,Paul F. Pilch +8 more
TL;DR: The data suggest that p115 has an important and specific role in insulin-stimulated GlUT4 translocation, probably by way of tethering insulin-sensitive Glut4 vesicles at an as yet unknown intracellular site.
Journal ArticleDOI
Role of vesicle tethering factors in the ER-Golgi membrane traffic.
TL;DR: This review highlights findings that support the model that multiple tether‐facilitated events are required to provide selectivity to vesicle fusion and indicates that tethers are more than static bridges.
Journal ArticleDOI
GMx33 Associates with the Trans-Golgi Matrix in a Dynamic Manner and Sorts within Tubules Exiting the Golgi
TL;DR: It is demonstrated that GMx33 is dynamically associated with the trans-Golgi matrix, associating and dissociating with the Golgi in seconds, and GTPgammaS indicates that its association is regulated in a GTP-dependent manner like several other Golgi matrix proteins.
References
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Journal ArticleDOI
Intracellular aspects of the process of protein synthesis
TL;DR: The title of the Nobel Lecture of George Palade (1 August, p. 347) should have been "Intracellular aspects of the process of protein secretion."
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Characterization of a cis-Golgi matrix protein, GM130
Nobuhiro Nakamura,Catherine Rabouille,Rose Watson,Tommy Nilsson,N Hui,P Slusarewicz,Thomas E. Kreis,Graham Warren +7 more
TL;DR: Biochemical data and predictions from the protein sequence suggest that GM130 is part of a cis-Golgi matrix and has a role in maintaining cis- Golgi structure.
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Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors.
TL;DR: Members of one subclass of Sec7-domain proteins are direct targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange reaction by trapping a reaction intermediate in an inactive, abortive complex.
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Secretory Protein Trafficking and Organelle Dynamics in Living Cells
TL;DR: Results from this work are clarifying the steps involved in the formation, translocation, and fusion of transport intermediates; the organization and biogenesis of organelles; and the mechanisms of protein retention, sorting, and recycling in the secretory pathway.
Journal ArticleDOI
Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion
TL;DR: It is proposed that Rab1-regulated assembly of functional effector-SNARE complexes defines a conserved molecular mechanism to coordinate recognition between subcellular compartments.