Journal ArticleDOI
Metabolic and toxic effects of mithramycin during tumor therapy.
TLDR
Mithramycin, an inhibitor of the synthesis of ribonucleic acid (RNA), was administered to fifty-eight patients with a variety of advanced carcinomas, and striking objective improvement occurred in embryonal cell cancer of the testis.About:
This article is published in The American Journal of Medicine.The article was published on 1970-10-01. It has received 147 citations till now. The article focuses on the topics: RNA & Toxicity.read more
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Drug Prescribing in Renal Failure: Dosing Guidelines for Adults
William M. Bennett,George R. Aronoff,Gail Morrison,Thomas A. Golper,Joseph P. Pulliam,Marsha Wolfson,Irwin Singer +6 more
TL;DR: The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency is presented in tabular form in this paper, where recommendations are based on pharmacokinetic variables in normal subjects.
Journal ArticleDOI
Hepatotoxicity of Chemotherapy
Paul D. King,Michael C. Perry +1 more
TL;DR: A comprehensive understanding of hepatotoxic manifestations for the most common chemotherapeutic agents is essential because dose modifications often rely on empirical clinical judgement.
Journal ArticleDOI
Drug-induced liver injury
Raúl J. Andrade,Naga Chalasani,Einar Bjornsson,Ayako Suzuki,Ayako Suzuki,Gerd A. Kullak-Ublick,Gerd A. Kullak-Ublick,Paul B. Watkins,Harshad Devarbhavi,Michael Merz,Michael Merz,M. Isabel Lucena,Neil Kaplowitz,Guruprasad P. Aithal +13 more
TL;DR: Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use as discussed by the authors.
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Nephrotoxicity Induced by Cancer Chemotherapy With Special Emphasis on Cisplatin Toxicity
Fernand Ries,Jean Klastersky +1 more
TL;DR: Cisplatin nephrotoxicity is clearly dose-related and used to be considered dose limiting; hyperhydration with mannitol-induced saline diuresis may allow administration of high doses and thus circumvent the dose-limiting effect of cisplatin-induced renal toxicity.
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Mucocutaneous reactions to chemotherapy
TL;DR: In this paper, the authors elaborate on previous descriptions of the cutaneous manifestations of chemotherapeutic treatment and discuss more recent findings and learn to generate a differential diagnosis of possible etiologies for varying patterns of cutaneous involvement in patients receiving chemotherapy.
References
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Journal ArticleDOI
Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs
TL;DR: Chromomycin and olivomycin form complexes with DNA, preferably in the helical form, but not with RNA, and none of the other antibiotics requires the presence of any single base in the template for its action.
Journal ArticleDOI
Mithramycin treatment of hypercalcemia.
Charles P. Perlia,Nancy J. Gubisch,J Wolter,David Edelberg,Margarida M. Dederick,Samuel G. Taylor +5 more
TL;DR: Mithramycin given by direct, single, intravenous injection of 25 μg/kg was effective in lowering serum calciums within 24 to 48 hours in the majority of patients studied.
Journal ArticleDOI
Mithramycin in the treatment of disseminated testicular neoplasms.
John H. Brown,B. J. Kennedy +1 more
TL;DR: There is a consistently poor prognosis for testicular neoplasms of germinal origin and a recently introduced antibiotic, mithramycin, has demonstrated striking antitumor activity in testicularNeoplasms, especially the embryonal-cell carcinoma.
Journal Article
Mithramycin inhibition of ribonucleic acid synthesis.
TL;DR: Mithramycin, an antibiotic derived from an organism belonging to the genus Streptomyces, was studied in mouse ascites tumor and mouse liver by measuring its effect on the incorporation of phosphate-32P into RNA and DNA in vitro and in vivo.
Journal ArticleDOI
Effects of Mithramycin on Paget's Disease of Bone
TL;DR: In this paper, the administration of mithramycin (25 µg/kg/day for 10 days) to two patients with Paget's disease of bone resulted in clearcut beneficial effects.