Metabolically healthy obesity and risk of mortality Does the definition of metabolic health matter
Guy-Marino Hinnouho,Sébastien Czernichow,Aline Dugravot,G. David Batty,Mika Kivimäki,Archana Singh-Manoux +5 more
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For most definitions of metabolic health, both metabolically healthy and unhealthy obese patients carry an elevated risk of mortality.Abstract:
To assess the association of a "metabolically healthy obese" phenotype with mortality using five definitions of metabolic health. Adults (n = 5,269; 71.7% men) aged 39-62 years in 1991 through 1993 provided data on BMI and metabolic health, defined using data from the Adult Treatment Panel-III (ATP-III); criteria from two studies; and the Matsuda and homeostasis model assessment (HOMA) indices. Cross-classification of BMI categories and metabolic status (healthy/unhealthy) created six groups. Cox proportional hazards regression models were used to analyze associations with all-cause and cardiovascular disease (CVD) mortality during a median follow-up of 17.7 years. A total of 638 individuals (12.1% of the cohort) were obese, of whom 9-41% were metabolically healthy, depending on the definition. Regardless of the definition, compared with metabolically healthy, normal-weight individuals, both the metabolically healthy obese (hazard ratios [HRs] ranged from 1.81 [95% CI 1.16-2.84] for ATP-III to 2.30 [1.13-4.70] for the Matsuda index) and the metabolically abnormal obese (HRs ranged from 1.57 [1.08-2.28] for the Matsuda index to 2.05 [1.44-2.92] for criteria defined in a separate study) had an increased risk of mortality. The only exception was the lack of excess risk using the HOMA criterion for the metabolically healthy obese (1.08; 0.67-1.74). Among the obese, the risk of mortality did not vary as a function of metabolic health apart from when using the HOMA criterion (1.93; 1.15-3.22). Similar results were obtained for cardiovascular mortality. For most definitions of metabolic health, both metabolically healthy and unhealthy obese patients carry an elevated risk of mortality.read more
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The Metabolic Health Index Identifies Patients That Will Benefit From Metabolic Surgery.
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TL;DR: In this article , the authors describe the use of the metabolic health index (MHI) as a supportive tool in the decision for and outcome assessment of bariatric surgery, and test the general usability of the MHI was tested by extending its application to patient data of five other bariatric centers in the Netherlands.
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Metabolically Healthy Obesity: Are Interventions Useful?
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