Metabolism-based therapies for epilepsy: new directions for future cures.
Mackenzie C. Cervenka,Juan M. Pascual,Jong M. Rho,Elizabeth A. Thiele,Gary Yellen,Vicky Whittemore,Adam L. Hartman +6 more
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TLDR
In this paper, the state of the science in metabolism-based therapies for epilepsy across the research lifecycle from basic to translational to clinical studies is considered, and a conceptual framework for creative, rigorous, and transparent research to benefit people with epilepsy through the understanding and modification of metabolism.Abstract:
OBJECTIVE Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism-based therapies are not always effective. METHODS We consider the state of the science in metabolism-based therapies for epilepsy across the research lifecycle from basic to translational to clinical studies. RESULTS This analysis creates a conceptual framework for creative, rigorous, and transparent research to benefit people with epilepsy through the understanding and modification of metabolism. INTERPRETATION Despite intensive past efforts to evaluate metabolism-based therapies for epilepsy, distinct ways of framing a problem offer the chance to engage different mindsets and new (or newly applied) technologies. A comprehensive, creative, and inclusive problem-directed research agenda is needed, with a renewed and stringent adherence to rigor and transparency across all levels of investigation.read more
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Combination of triheptanoin with the ketogenic diet in Glucose transporter type 1 deficiency (G1D)
Adrian Avila,Deepa Sirsi,Saima N Kayani,Sharon Primeaux,Gauri Kathote,Vikram Jakkamsetti,Raja Reddy Kallem,William C. Putnam,Jason Y. Park,Shlomo Shinnar,Juan M. Pascual +10 more
TL;DR: In this paper , the compatibility of triheptanoin at maximum tolerable dose with the ketogenic diet was examined in 10 Glucose transporter type 1 deficiency (G1D) individuals using clinical and electroencephalographic analyses, glycemia, and four and five-carbon ketosis.
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