Journal ArticleDOI
Metabolism of 5-hydroxy-4-keto-valeric acid in the rat.
TLDR
Formation of these products suggests that HKV may be converted to 2-keto-glutamate and delta-aminolevulinic acid via 4,5-dioxo-valerate, and in vivo oxidation of 14C-HKV to 14CO2 is shown in the rat.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1970-08-11. It has received 12 citations till now. The article focuses on the topics: Valeric acid & Decarboxylation.read more
Citations
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Journal ArticleDOI
Biosynthesis of delta-aminolevulinic acid from the intact carbon skeleton of glutamic acid in greening barley.
TL;DR: Demonstration of the new pathway in plants has been made by feeding specifically labeled [14C]glutamic acid to etiolated barley shoots greening in the light, and the labeling pattern for delta-aminolevulinic acid is consistent with a biosynthetic route utilizing the intact five-carbon skeleton of alpha-ketoglutarate, glutamate, or glutamine.
Journal ArticleDOI
Biosynthesis of porphyrin precursors. Purification and characterization of mammalian L-alanine:gamma,delta-dioxovaleric acid aminotransferase.
TL;DR: Although the enzyme appeared to be a typical transaminase, exhaustive experiments failed to demonstrate reversibility of the reaction and the possibility that gamma,delta-dioxovalerate transaminases plays a role in the biosynthesis of delta-aminolevulinic acid in vivo must be considered.
Journal ArticleDOI
AMP Analogs: Their Function in the Activation of Glycogen Phosphorylase b
TL;DR: It is shown that the 5'-phosphate moiety is absolutely required for the analog to bind at the correct site (adenine or adenosine bind at another enzymic site), and that the free enthalpy, delta G, corresponding to the association process varies in a complex manner with respect to the substitution of the different positions of the AMP molecule.
Journal ArticleDOI
5-Hydroxylevulinic acid, a new intermediate in the biosynthesis of protoanemonin
TL;DR: In this article, a scheme for the biosynthesis of the antibiotic protoanemonin and its glucosidic precursors is proposed, which is shown that 5-(β- d -glucopyranosyloxy)levulinic acid could be the genuine precursor of all the compounds studied.
References
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Journal ArticleDOI
THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE
D. Mauzerall,S. Granick +1 more
TL;DR: A sensitive calorimetric method for the quantitative determination of SAL is described and 6AL has been found in urine of a patient with acute porphyria and also in normal urine.
Journal ArticleDOI
Anion exchange chromatography of acids of the citric acid cycle.
TL;DR: This study is-an extension of the use of ion exchange resins to the separation of acids of the Krebs cycle by using these resins for chromatographic separation of individual amino acids.
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A Sensitive Radiochemical Assay Method for δ-Aminolevulinic Acid Synthetase
TL;DR: It has been found that the normal level of ALA synthetase activity in guinea pig liver mitochondria is even less than hitherto believed from colorimetric assays and cannot with confidence be said to be significantly above zero.
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Continuous C14O2 and CO2 Excretion Studies in Experimental Animals
TL;DR: The instrument can be readily adapted for use in large animal or human studies following administration of small amounts of C 14, and gives an excellent indication of the continuous and steady processes by which radioactivity is distributed into the various body pools.
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THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE
D. Mauzerall,S. Granick +1 more