Metabolism of drugs by the kidney
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TLDR
A complete perspective on the role of the kidney in pharmacologic and toxicologic processes is dependent on a thorough understanding of the drug and chemical metabolic capabilities of this organ.About:
This article is published in Kidney International.The article was published on 1980-11-01 and is currently open access. It has received 181 citations till now. The article focuses on the topics: Drug metabolism & Metabolite.read more
Citations
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Renal Toxicity of the Nonsteroidal Anti-Inflammatory Drugs
Michael D. Murray,D C Brater +1 more
TL;DR: An important issue to be resolved is the relationship between the acute, reversible, prostaglandin-mediated renal effects of the NSAIDs and chronic, irreversible destruction, if such a relationship exists.
Journal Article
Renal Drug Metabolism
TL;DR: The kidneys have important physiological functions including maintenance of water and electrolyte balance, synthesis, metabolism and secretion of hormones, and excretion of the waste products from metabolism.
Journal ArticleDOI
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.
TL;DR: agents that inhibit gamma-glutamyl transpeptidase, cysteine conjugate beta-lyase, and renal organic anion transport systems, namely L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, and probenecid protected against S-conjugate-induced nephrotoxicity.
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The effect of chronic renal failure on drug metabolism and transport
TL;DR: Animal studies in CRF have shown a significant downregulation of hepatic and intestinal CYP metabolism, producing a clinically significant impact on drug disposition and increasing the risk for adverse drug reactions.
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Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.
TL;DR: The material presented in this review deals with the hypothesis that the nephrotoxicity of certain halogenated alkanes and alkenes is associated with hepatic biosynthesis of glutathione S-conjugates, which are further metabolized to the corresponding cysteine S- Conjugates.
References
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Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal Article
Pharmacological implications of microsomal enzyme induction
TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
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Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.
TL;DR: The data suggest that the hepatic cytosol species which binds TCDD is the receptor for the induction of hepatic aryl hydrocarbon hydroxylase activity, and that the mutation in nonresponsive mice results in an altered receptor with a diminished affinity for inducing compounds.