Patent
Method and system for patient-specific modeling of blood flow
TLDR
In this article, a system for determining cardiovascular information for a patient is described, which includes at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the heart based on the patient specific data.Abstract:
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.read more
Citations
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Physiological measurement communications adapter
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Method and system for machine learning based assessment of fractional flow reserve
Puneet Sharma,Ali Kamen,Bogdan Georgescu,Frank Sauer,Dorin Comaniciu,Yefeng Zheng,Hien M. Nguyen,Vivek Kumar Singh +7 more
TL;DR: In this paper, a method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed, where a set of features for the stenosis is extracted from the medical image data of the patient, and an FFR value is determined based on the extracted set of feature using a trained machine-learning based mapping.
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Method and system for non-invasive assessment of coronary artery disease
TL;DR: In this article, an anatomical model of a coronary artery is generated from the medical image data, based on a spatio-temporal representation of contrast agent propagation, and the estimated velocity of the blood in the coronary artery as a boundary condition.
References
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Hemodynamic shear stress and its role in atherosclerosis.
TL;DR: The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.
Journal ArticleDOI
Measurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses
Nico H.J. Pijls,Bernard De Bruyne,Kathinka H. Peels,Pepijn H. van der Voort,Hans Bonnier,Jozef Bartunek,Jacques J. Koolen +6 more
TL;DR: In patients with coronary stenosis of moderate severity, FFR appears to be a useful index of the functional severity of the stenoses and the need for coronary revascularization.
Journal ArticleDOI
Percutaneous Coronary Intervention of Functionally Nonsignificant Stenosis: 5-Year Follow-Up of the DEFER Study
Nico H.J. Pijls,Pepijn van Schaardenburgh,Ganesh Manoharan,Eric Boersma,Jan-Willem Bech,Marcel van 't Veer,Frits W. Bär,Jan C.A. Hoorntje,Jacques J. Koolen,William Wijns,Bernard De Bruyne +10 more
TL;DR: Five-year outcome after deferral of PCI of an intermediate coronary stenosis based on FFR >/=0.75 is excellent and the risk of cardiac death or myocardial infarction related to this stenosis is <1% per year and not decreased by stenting.
Journal ArticleDOI
Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome.
Sadako Motoyama,Masayoshi Sarai,Hiroto Harigaya,Hirofumi Anno,Kaori Inoue,Tomonori Hara,Hiroyuki Naruse,Junichi Ishii,Hitoshi Hishida,Nathan D. Wong,Renu Virmani,Takeshi Kondo,Yukio Ozaki,Jagat Narula +13 more
TL;DR: Patients demonstrating positively remodeled coronary segments with low-attenuation plaques on CT angiography were at a higher risk of ACS developing over time when compared with patients having lesions without these characteristics.
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Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms : Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) Study
Bon-Kwon Koo,Andrejs Erglis,Joon Hyung Doh,David V. Daniels,Sanda Jegere,Hyo-Soo Kim,Allison Dunning,Tony DeFrance,Alexandra J. Lansky,Jonathan Leipsic,James K. Min +10 more
TL;DR: Noninvasive FFR derived from CCTA is a novel method with high diagnostic performance for the detection and exclusion of coronary lesions that cause ischemia.