Midlife hand grip strength as a predictor of old age disability.
Taina Rantanen,J. M. Guralnik,Daniel J. Foley,K. H. Masaki,Suzanne G. Leveille,J D Curb,Laurens P. White +6 more
TLDR
Among healthy 45- to 68-year-old men, hand grip strength was highly predictive of functional limitations and disability 25 years later, suggesting good muscle strength in midlife may protect people from old age disability by providing a greater safety margin above the threshold of disability.Abstract:
ContextPoor muscle strength, functional limitations, and
disability often coexist, but whether muscle strength during midlife
predicts old age functional ability is not known.ObjectiveTo determine whether hand grip strength measured during
midlife predicts old age functional limitations and disability in
initially healthy men.Design and SettingA 25-year prospective cohort study, the
Honolulu Heart Program, which began in 1965 among Japanese-American men
living on Oahu, Hawaii.ParticipantsA total of 6089 45- to 68-year-old men who
were healthy at baseline and whose maximal hand grip strength was
measured from 1965 through 1970. Altogether, 2259 men died over the
follow-up period and 3218 survivors participated in the disability
assessment in 1991 through 1993.Main Outcome MeasuresFunctional limitations including slow
customary walking speed (≤0.4 m/s) and inability to rise from a seated
position without using the arms, and multiple self-reported upper
extremity, mobility, and self-care disability outcomes.ResultsAfter adjustment for multiple potential confounders, risk
of functional limitations and disability 25 years later increased as
baseline hand grip strength, divided into tertiles, declined. The odds
ratio (OR) of walking speed of 0.4 m/s or slower was 2.87 (95%
confidence interval [CI], 1.76-4.67) in those in the lowest third and
1.79 (95% CI, 1.14-2.81) in the middle third of grip strength vs those
in the highest third. The risk of self-care disability was more than 2
times greater in the lowest vs the highest grip strength tertile.
Adding chronic conditions identified at follow-up to the models
predicting disability reduced the ORs related to grip strength only
minimally.ConclusionsAmong healthy 45- to 68-year-old men, hand grip
strength was highly predictive of functional limitations and disability
25 years later. Good muscle strength in midlife may protect people from
old age disability by providing a greater safety margin above the
threshold of disability.read more
Citations
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Journal ArticleDOI
Exercise and physical activity for older adults
Wojtek Chodzko-Zajko,David N. Proctor,Maria A. Fiatarone Singh,Christopher T. Minson,Claudio R. Nigg,George J. Salem,James S. Skinner +6 more
TL;DR: The evidence reviewed in this Position Stand is generally consistent with prior American College of Sports Medicine statements on the types and amounts of physical activity recommended for older adults as well as the recently published 2008 Physical Activity Guidelines for Americans.
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Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.
TL;DR: To establish the prevalence of sarc Openia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons is established.
Journal ArticleDOI
The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Bret H. Goodpaster,Seok Won Park,Tamara B. Harris,S. B. Kritchevsky,Michael C. Nevitt,Ann V. Schwartz,Eleanor M. Simonsick,Frances A. Tylavsky,Marjolein Visser,Anne B. Newman +9 more
TL;DR: Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of Muscle mass, suggesting a decline in muscle quality.
Journal ArticleDOI
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
Fulvio Lauretani,Cosimo Roberto Russo,Stefania Bandinelli,Benedetta Bartali,Chiara Cavazzini,Angelo Di Iorio,Anna Maria Corsi,Taina Rantanen,Jack M. Guralnik,Luigi Ferrucci +9 more
TL;DR: Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed and lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength.
Journal ArticleDOI
Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort
Anne B. Newman,Varant Kupelian,Marjolein Visser,Eleanor M. Simonsick,Bret H. Goodpaster,Stephen B. Kritchevsky,Frances A. Tylavsky,Susan M. Rubin,Tamara B. Harris +8 more
TL;DR: Low muscle mass did not explain the strong association of strength with mortality, demonstrating that muscle strength as a marker of muscle quality is more important than quantity in estimating mortality risk.
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