Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort
Anne B. Newman,Varant Kupelian,Marjolein Visser,Eleanor M. Simonsick,Bret H. Goodpaster,Stephen B. Kritchevsky,Frances A. Tylavsky,Susan M. Rubin,Tamara B. Harris +8 more
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TLDR
Low muscle mass did not explain the strong association of strength with mortality, demonstrating that muscle strength as a marker of muscle quality is more important than quantity in estimating mortality risk.Abstract:
Background. Although muscle strength and mass are highly correlated, the relationship between direct measures of low muscle mass (sarcopenia) and strength in association with mortality has not been examined. Methods. Total mortality rates were examined in the Health, Aging and Body Composition (Health ABC) Study in 2292 participants (aged 70–79 years, 51.6% women, and 38.8% black). Knee extension strength was measured with isokinetic dynamometry, grip strength with isometric dynamometry. Thigh muscle area was measured by computed tomography (CT) scan, and leg and arm lean soft tissue mass were determined by dual energy x-ray absorptiometry (DXA). Both strength and muscle size were assessed as in gender-specific Cox proportional hazards models, with age, race, comorbidities, smoking status, level of physical activity, fat area by CT or fat mass by DXA, height, and markers of inflammation, including interleukin-6, C-reactive protein, and tumor necrosis factor-a considered as potential confounders. Results. There were 286 deaths over an average of 4.9 (standard deviation ¼ 0.9) years of follow-up. Both quadriceps and grip strength were strongly related to mortality. For quadriceps strength (per standard deviation of 38 Nm), the crude hazard ratio for men was 1.51 (95% confidence interval, 1.28–1.79) and 1.65 (95% confidence interval, 1.19–2.30) for women. Muscle size, determined by either CT area or DXA regional lean mass, was not strongly related to mortality. In the models of quadriceps strength and mortality, adjustment for muscle area or regional lean mass only slightly attenuated the associations. Further adjustment for other factors also had minimal effect on the association of quadriceps strength with mortality. Associations of grip strength with mortality were similar. Conclusion. Low muscle mass did not explain the strong association of strength with mortality, demonstrating that muscle strength as a marker of muscle quality is more important than quantity in estimating mortality risk. Grip strength provided risk estimates similar to those of quadriceps strength.read more
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Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise
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TL;DR: The recommended quantity and quality of exercise for developing and maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in healthy adults is discussed in the position stand of the American College of Sports Medicine (ACSM) Position Stand.
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TL;DR: The AWGS consensus report is believed to promote more Asian sarcopenia research, and most important of all, to focus on sarc Openia intervention studies and the implementation of sarcopenian in clinical practice to improve health care outcomes of older people in the communities and the healthcare settings in Asia.
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Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
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TL;DR: Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions.
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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Bret H. Goodpaster,Seok Won Park,Tamara B. Harris,S. B. Kritchevsky,Michael C. Nevitt,Ann V. Schwartz,Eleanor M. Simonsick,Frances A. Tylavsky,Marjolein Visser,Anne B. Newman +9 more
TL;DR: Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of Muscle mass, suggesting a decline in muscle quality.
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The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
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TL;DR: Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 forMen and women.
References
More filters
Journal ArticleDOI
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
Journal ArticleDOI
A questionnaire for the assessment of leisure time physical activities.
Henry Longstreet Taylor,David R. Jacobs,Beth Schucker,Joan Knudsen,Arthur S. Leon,Guy Debacker +5 more
TL;DR: A questionnaire for evaluating energy expenditure in leisure time physical activity (LTA) along with information about its validity is presented in this paper, which is valid for use in longitudinal studies in North America of the relationship of physical activity to disease, in weight control clinics and in other researches in which leisure-time physical activity is of interest.
Journal ArticleDOI
Midlife hand grip strength as a predictor of old age disability.
Taina Rantanen,J. M. Guralnik,Daniel J. Foley,K. H. Masaki,Suzanne G. Leveille,J D Curb,Laurens P. White +6 more
TL;DR: Among healthy 45- to 68-year-old men, hand grip strength was highly predictive of functional limitations and disability 25 years later, suggesting good muscle strength in midlife may protect people from old age disability by providing a greater safety margin above the threshold of disability.
Journal ArticleDOI
Strength conditioning in older men: skeletal muscle hypertrophy and improved function.
TL;DR: Strength gains in older men were associated with significant muscle hypertrophy and an increase in myofibrillar protein turnover and the torque-velocity relationship showed an upward displacement of the curve at the end of training, mainly in the slow-vel velocity high-torque region.
Journal ArticleDOI
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study.
Marjolein Visser,Marco Pahor,Dennis R. Taaffe,Bret H. Goodpaster,Eleanor M. Simonsick,Anne B. Newman,Michael C. Nevitt,Tamara B. Harris +7 more
TL;DR: Higher plasma concentrations of IL-6 and TNF-alpha are associated with lower muscle mass and lower muscle strength in well-functioning older men and women, and may contribute to the loss of Muscle mass and strength that accompanies aging.