Mode of action of metronidazole on anaerobic bacteria and protozoa
TLDR
Metronidazole and related 5-nitroimidazoles are relatively nontoxic, however, reduction of their nitro group leads to the production of short-lived cytotoxic intermediates, which finally decompose into nontoxic end products.About:
This article is published in Surgery.The article was published on 1983-01-01 and is currently open access. It has received 179 citations till now. The article focuses on the topics: Anaerobic bacteria & Microbial metabolism.read more
Citations
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Journal ArticleDOI
Treatment of Giardiasis
Timothy B. Gardner,David R. Hill +1 more
TL;DR: Each class of drugs used in treatment is discussed, along with their mechanism of action, in vitro and clinical efficacy, and side effects and contraindications, and Recommendations are made for the preferred treatment in different clinical situations.
Journal ArticleDOI
Metronidazole. A therapeutic review and update.
TL;DR: Advantages to using metronidazole are the percentage of sensitive Gram-negative anaerobes, its availability as oral and intravenous dosage forms, its rapid bacterial killing, its good tissue penetration, its considerably lower chance of inducing C. difficile colitis, and expense.
Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.
TL;DR: The concentration-dependent bactericidal activity, prolonged half-life and sustained activity in plasma support the clinical evaluation of higher doses of metronidazole given less frequently, and the pharmacokinetics are unaffected by acute or chronic renal failure, haemodialysis, continuous ambulatory peritoneal dialysis, age, pregnancy or enteric disease.
Journal ArticleDOI
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
TL;DR: Polyoxometalates (PMs) as discrete metal-oxide cluster anions comprise a versatile class of inorganic, anionic clusters that have a wide variety of structures, sizes, and a combination of metals, high solubility in water, and electrochemical activity as discussed by the authors.
Book ChapterDOI
Giardia and Giardiasis
TL;DR: The intention here is to give an up-to-date overview of Giardia and giardiasis and provide an insight into the enormous wealth of literature on the subject, as well as highlight the most important recent developments and unresolved questions.
References
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Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles
Donald G. Lindmark,Miklós Müller +1 more
TL;DR: The results underscore the role of the reduction of the nitro group in the antitrichomonad and in the mutagenic activity of nitroimidazoles.
Journal ArticleDOI
The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms
TL;DR: Inhibition of nucleic acid synthesis was demonstrated in both this and other drug-sensitive organisms at drug concentrations as low as 1 μg/ml and a possible mechanism of action of the drug has been postulated.
Journal ArticleDOI
Energy metabolism of the anaerobic protozoon Giardia lamblia.
TL;DR: The results suggest the occurrence of glycolysis, energy production by substrate level phosphorylation and a flavin, iron-sulfur protein mediated electron transport system as well as the absence of cytochrome mediated oxidative phosphorylated and functional Krebs cycle.
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An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.
TL;DR: It is postulated that in bacteria-grown amebae electrons generated at the pyruvate synthase step are utilized anaerobically to produce H2 via the hydrogenase and that the acetyl-CoA is converted to acetate in an energy-conserving step catalyzed by amebal acetyl -CoA synthetase.
Journal ArticleDOI
Strain of Trichomonas vaginalis Resistant to Metronidazole and Other 5-Nitroimidazoles
TL;DR: A strain of Trichomonas vaginalis (IR-78), recently isolated from a patient afflicted with recurrent symptomatic trichomoniasis, showed resistance to metronidazole, tinidazoles, and nimorazole in vitro as well as in vivo.
Related Papers (5)
The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms
Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles
Donald G. Lindmark,Miklós Müller +1 more