Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits.
TLDR
Results indicate that beta gamma subunits influence phospholipase C activity in a concentration range similar to that necessary for regulation of adenylate cyclase activity and suggest the involvement of a G-protein possessing an alpha beta gamma heterotrimeric structure in coupling hormone receptors to phospholIPase C.About:
This article is published in Journal of Biological Chemistry.The article was published on 1989-08-15 and is currently open access. It has received 81 citations till now. The article focuses on the topics: G alpha subunit & Phospholipase C.read more
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Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
TL;DR: Current research in this area is directed toward the identification and structural characterization of nucleotide or P2-purinergic receptors that are activated when ATP or other nucleotides are bound.
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Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq
TL;DR: The alpha subunit of a newly discovered pertussis toxin-insensitive G protein (Gq) has recently been isolated and is shown to stimulate the activity of polyphosphoinositide-specific phospholipase C (PI-PLC) from bovine brain, identifying Gq as a G protein that regulates PI-P LC.
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Physiological regulation of G protein-linked signaling.
Andrew J. Morris,Craig C. Malbon +1 more
TL;DR: Physiological regulation of G protein-linked receptors allows for integration of signals that directly or indirectly effect the signaling from receptor-->G protein-->effector(s).
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Different β-subunits determine G-protein interaction with transmembrane receptors
TL;DR: It is shown that two out of four subtypes of β-subunits tested (β1 and β3) are selectively involved in the signal transduction cascades from muscarinic M4 and somatostatin receptors, respectively, to voltage-dependent Ca2+ channels.
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Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors.
TL;DR: The presence of multiple isoforms of PLC which bear minimal relationship was already a clear indication that differential regulation may occur, and this review focuses on the recent explosion in knowledge regarding the regulation of the phospholipases by receptors.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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A Highly Sensitive Adenylate Cyclase Assay
TL;DR: The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies.
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Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain
TL;DR: The alpha subunit of GO was isolated without the use of ligands known to dissociate other G proteins, and should be of great utility in elucidating the mechanism of action of this family of GTP-binding proteins.
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Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase.
TL;DR: Evidence that mast cell secretion is inhibited by internalized neomycin, a compound known to interact with PPI, and the PPI phosphodiesterase of human neutrophil plasma membranes can be activated simply by adding GTP analogues in the presence of concentrations of Ca2+ that pertain in unstimulated cells are provided.