A
Andrew J. Morris
Researcher at University of Kentucky
Publications - 275
Citations - 19306
Andrew J. Morris is an academic researcher from University of Kentucky. The author has contributed to research in topics: Lysophosphatidic acid & Phospholipase D. The author has an hindex of 64, co-authored 275 publications receiving 17352 citations. Previous affiliations of Andrew J. Morris include United States Department of Veterans Affairs & State University of New York System.
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Journal ArticleDOI
Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation
Akira Honda,Masahiro Nogami,Takeaki Yokozeki,Masakazu Yamazaki,Hiroshi Nakamura,Hiroshi Watanabe,Kazumasa Kawamoto,Kazuhisa Nakayama,Andrew J. Morris,Michael A. Frohman,Yasunori Kanaho +10 more
TL;DR: PI(4)P5Kalpha is a downstream effector of ARF 6 and when ARF6 is activated by agonist stimulation, it triggers recruitment of a diverse but interactive set of signaling molecules into sites of active cytoskeletal and membrane rearrangement.
Journal ArticleDOI
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
William C. Colley,Tsung-Chang Sung,Richard Roll,John Jenco,Scott M. Hammond,Yelena M. Altshuller,Dafna Bar-Sagi,Andrew J. Morris,Michael A. Frohman +8 more
TL;DR: PLD2 is a newly identified mammalian PLD isoform with novel regulatory properties that provokes cortical reorganization and undergoes redistribution in serum-stimulated cells, suggesting that it may have a role in signal-induced cytoskeletal regulation and/or endocytosis.
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Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family
Scott M. Hammond,Yelena M. Altshuller,Tsung Chang Sung,Simon A. Rudge,Kristine Rose,JoAnne Engebrecht,Andrew J. Morris,Michael A. Frohman +7 more
TL;DR: The identification of the first human PLD cDNA is reported, which defines a new and highly conserved gene family and likely encodes the gene product responsible for the most widely studied endogenous PLD activity.
Journal ArticleDOI
Characterization of Two Alternately Spliced Forms of Phospholipase D1 ACTIVATION OF THE PURIFIED ENZYMES BY PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, ADP-RIBOSYLATION FACTOR, AND RHO FAMILY MONOMERIC GTP-BINDING PROTEINS AND PROTEIN KINASE C-α
Scott M. Hammond,John M. Jenco,Shigeru Nakashima,Karen Cadwallader,Qu Ming Gu,Simon J. Cook,Yoshinori Nozawa,Glenn D. Prestwich,Glenn D. Prestwich,Michael A. Frohman,Andrew J. Morris +10 more
TL;DR: An evolutionarily conserved shorter splice variant of PLD1 lacking 38 amino acids is identified that arises from regulated splicing of an alternate exon, suggesting that these three classes of regulators interact with different sites on the enzyme.
Journal ArticleDOI
Bayesian refinement of association signals for 14 loci in 3 common diseases.
Julian Maller,Gilean McVean,Gilean McVean,Jake K. Byrnes,Damjan Vukcevic,Kimmo Palin,Zhan Su,Joanna M. M. Howson,Adam Auton,Simon Myers,Simon Myers,Andrew J. Morris,Matti Pirinen,Matthew A. Brown,Matthew A. Brown,Paul Burton,Mark J. Caulfield,Alastair Compston,Martin Farrall,Alistair S. Hall,Andrew T. Hattersley,Adrian V. S. Hill,Christopher G. Mathew,Marcus Pembrey,Jack Satsangi,Michael R. Stratton,Jane Worthington,Nicholas John Craddock,Matthew E. Hurles,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Miles Parkes,Nazneen Rahman,Audrey Duncanson,John A. Todd,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Nilesh J. Samani,Nilesh J. Samani,Stephen C. L. Gough,Stephen C. L. Gough,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Panagiotis Deloukas,Peter Donnelly,Peter Donnelly +47 more
TL;DR: In this paper, the authors defined credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs, and showed the value of more detailed mapping to target sequences for functional studies.