Journal ArticleDOI
Modified taxols. 5. Reaction of taxol with electrophilic reagents and preparation of a rearranged taxol derivative with tubulin assembly activity
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This article is published in Journal of Organic Chemistry.The article was published on 1991-08-01. It has received 222 citations till now.read more
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Chemistry and Biology of Taxol
TL;DR: This account attempts to bring together in a cogent overview the chemistry and biology of taxol, one of the few organic compounds, which, like benzene and aspirin, is recognizable by name to the average citizen.
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Taxol and taxotere: discovery, chemistry, and structure-activity relationships
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Plant-based anticancer molecules: a chemical and biological profile of some important leads.
TL;DR: Four important anticancer leads are focused on, that is, camptothecin, taxol, combretastatin A-4 and podophyllotoxin, whose chemistry, structure and activity relationships, biological activities, modes of action, analogue synthesis and future prospects have been discussed.
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The taxane diterpenoids
TL;DR: The structures of over 350 taxane diterpenoids are classified and presented with information on their plant source, yield, melting point, and optical activity.
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The chemistry of taxol
TL;DR: The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.