Journal ArticleDOI
The chemistry of taxol
TLDR
The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.About:
This article is published in Pharmacology & Therapeutics.The article was published on 1991-10-01. It has received 275 citations till now.read more
Citations
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Journal ArticleDOI
A comparison of models for calculating nuclear magnetic resonance shielding tensors
TL;DR: In this article, the direct implementation of the GIAO and CSGT methods for calculating nuclear magnetic shielding tensors at both the Hartree-Fock and density functional levels of theory is presented.
Journal ArticleDOI
Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
TL;DR: Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
Patent
Anti-angiogenic compositions and methods of use
TL;DR: In this article, an anti-angiogenic factor and a polymeric carrier were used for embolization of blood vessels and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
Journal ArticleDOI
Chemistry and Biology of Taxol
TL;DR: This account attempts to bring together in a cogent overview the chemistry and biology of taxol, one of the few organic compounds, which, like benzene and aspirin, is recognizable by name to the average citizen.
References
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Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
Promotion of microtubule assembly in vitro by taxol
TL;DR: It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
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Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol
Israel Ringel,Susan Band Horwitz +1 more
TL;DR: RP 56976 (taxotere) is a potent inhibitor of cell replication and, like taxol, promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.
Journal ArticleDOI
Relationships between the structure of taxol analogues and their antimitotic activity.
Francoise Gueritte-Voegelein,Daniel Guenard,François Lavelle,M.-T. Le Goff,L. Mangatal,Pierre Jean-Paul Potier +5 more
TL;DR: This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'.