Journal ArticleDOI
Molecular structure and electronic spectrum of taspine : semiempirical calculations
Tsuguo Sato,Masahiro Kataoka +1 more
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In this article, the energy barrier between the enantiomeric structures and the Cs structure is calculated to be about 1 kcal/mol and the small barrier readily causes an intramolecular interconversion of the two enantiomers through the cs structure and thus results in the optical inactivity of taspine.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1999-07-01. It has received 2 citations till now. The article focuses on the topics: Taspine & CNDO/2.read more
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QSAR studies of the pyrethroid insecticides. Part 3. A putative pharmacophore derived using methodology based on molecular dynamics and hierarchical cluster analysis.
TL;DR: In this paper, a conformational analysis of a group of synthetic pyrethroid insecticides has been carried out and a parameterisation of the CHARMM force field for these compounds has been performed and the extra parameters reported.
Journal ArticleDOI
Molecular Structure and Electronic Spectrum of Taspine: Semiempirical Calculations.
Tsuguo Sato,Masahiro Kataoka +1 more
TL;DR: In this article, the energy barrier between the enantiomeric structures and the Cs structure is calculated to be about 1 kcal/mol and the small barrier readily causes an intramolecular interconversion of the two enantiomers through the cs structure and thus results in the optical inactivity of taspine.
References
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Journal ArticleDOI
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model
TL;DR: In this paper, a new parametric quantum mechanical molecular model, AM1 (Austin Model l), based on the NDDO approximation, is described, in which the major weaknesses of MNDO, in particular failure to reproduce hydrogen bonds, have been overcome without any increase in computing time.
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Isolation of a Dihydrobenzofuran Lignan from South American Dragon's Blood (Croton spp.) as an Inhibitor of Cell Proliferation
TL;DR: Bioassay-guided fractionation of dragon's blood, using an in vitro test system for the stimulation of human umbilical vein endothelial cells, has resulted in the isolation of a dihydrobenzofuran lignan, 3'O-dimethylcedrusin or 4-O-methyldihydrodehydrodiconiferyl alcohol as the biologically active principle.
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Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.
Abraham Vaisberg,Marcos Milla,Maria del Carmen Planas,Jose L. Cordova,Elva Rosas de Agusti,Ramon Ferreyra,Maria del Carmen Mustiga,Lily Carlin,Gerald B. Hammond +8 more
TL;DR: Using the two-stage mouse skin carcinogenesis system, it is shown that neither Sangre de Grado nor taspine hydrochloride had carcinogenic or tumour promoter activity after 17 months of treatment.
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Enhancement of wound healing by the alkaloid taspine defining mechanism of action.
TL;DR: The data suggest that taspine promotes early phases of wound healing in a dose-dependent manner with no substantial modification thereafter, and is probably related to its chemotactic properties on fibroblasts and is not mediated by changes in extracellular matrix.
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South American Plants II: Taspine Isolation and Anti-Inflammatory Activity
TL;DR: Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine, which was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model.