Monocyte-macrophage-derived acidic isoferritins: Normal feedback regulators of granulocyte-macrophage progenitor cells in vitro
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TLDR
The cells of origin and target cells of action suggest that acidic isoferritin-inhibitory activity can be considered as a negative feedback regulator, at least in vitro.About:
This article is published in Blood.The article was published on 1982-09-01 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Granulocyte-Macrophage Progenitor Cells & Monocyte.read more
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Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells
Hal E. Broxmeyer,Gordon W. Douglas,Giao Hangoc,Scott Cooper,Judith Bard,Denis English,Margaret Arny,Lewis Thomas,Edward A. Boyse +8 more
TL;DR: It was determined that granulocyte-macrophage, erythroid, and multipotential progenitor cells remained functionally viable in cord blood untreated except for addition of anticoagulant for at least 3 days at 4 degrees C or 25 degrees C (room temperature), though not at 37 degrees C, implying that these cells could be satisfactorily studied and used or cryopreserved for therapy.
Journal ArticleDOI
Granulocyte-Macrophage Colony-Stimulating Factor: Pleiotropic Cytokine with Potential Clinical Usefulness
Christian Ruef,David L. Coleman +1 more
TL;DR: Granulocyte-macrophage colony-stimulating factor significantly increased circulating numbers of several myeloid cells and produced dose-dependent toxicity consisting primarily of myalgias, fever, fluid retention, and serosal effusions.
Journal ArticleDOI
Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells.
Hal E. Broxmeyer,Scott Cooper,Li Lu,Giao Hangoc,Dirk Anderson,David J. Cosman,Stewart D. Lyman,Douglas E. Williams +7 more
TL;DR: MGF appears to be an early acting cytokine that preferentially stimulates the growth of immature hematopoietic progenitor cells and effects on BFU-E, CFU-GM, andCFU-GEMM may be direct acting ones as MGF-enhanced colony formation by these cells in highly enriched progenitors cell populations.
Journal ArticleDOI
Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin
TL;DR: An indirect mode of action and a specificity for activin and inhibin on multipotential and erythroid progenitor cells are defined.
References
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Journal ArticleDOI
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
Hugo Castro-Malaspina,Hugo Castro-Malaspina,Hugo Castro-Malaspina,Gene Resnick,Gene Resnick,Gene Resnick,Neena Kapoor,Neena Kapoor,Neena Kapoor,Paul A. Meyers,Paul A. Meyers,Paul A. Meyers,Dominick R. Chiarieri,Dominick R. Chiarieri,Dominick R. Chiarieri,Susan Mckenzie,Susan Mckenzie,Susan Mckenzie,Hal E. Broxmeyer,Hal E. Broxmeyer,Hal E. Broxmeyer,Malcolm A.S. Moore,Malcolm A.S. Moore,Malcolm A.S. Moore +23 more
TL;DR: Analysis of CFU-F proliferative status by the thymidine suicide technique indicated that this cell was noncycling in individuals with undisturbed bone marrow function and data support the conclusion that the colonies described in this study are of fibroblastic nature.
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Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production.
TL;DR: Microgram quantities of LF acted in vivo to inhibit rebound granulopoiesis and CSA production in CD1 and C57Bl/6 mice pretreated with cyclophosphamide, which strongly implicate LF as a physiological regulator of granulopsioiesis.
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Regulation of macrophage and granulocyte proliferation. Specificities of prostaglandin E and lactoferrin
TL;DR: Experimental evidence for a selective role of Macrophage PGE in the regulation of macrophage colony formation was directly provided by utilizing resident peritoneal macrophages as a source of CSF for bone marrow target cell overlays.
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Identification of leukemia-associated inhibitory activity as acidic isoferritins. A regulatory role for acidic isoferritins in the production of granulocytes and macrophages.
TL;DR: Results implicate acidic isoferritins in the regulation of normal myelopoiesis and suggest a role for them in the progression of leukemia.
Journal ArticleDOI
Colony formation in agar by multipotential hemopoietic cells.
TL;DR: Agar cultures of CBA fetal liver, peripheral blood, yolk sac and adult marrow cells were stimulated by pokeweed mitogen‐stimulated spleen conditioned medium to contain erythroid, neutrophil, macrophage, eosinophil and megakaryocytic cells, and no lymphoid cells were detected.