Journal ArticleDOI
Morphological changes in livers of rats fed polychlorinated biphenyls: light microscopy and ultrastructure.
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The effect of Aroclor 1254 on the liver was more pronounced than that of A RoClor 1260, and the epithelial component of adenofibrosis consisted of goblet cells and cells that resembled the epithelium which lines the bile ducts.Abstract:
Male and female Sherman strain rats were fed polychlorinated biphenyls Aroclor 1260 and Aroclor 1254 at 0, 20, 100, 500 and 1,000 ppm in their diet. Rats received the dietary levels for eight months. Light microscopic changes consisted of hypertrophy of the liver cells, inclusions in the cytoplasm, brown pigment in Kupffer cells, lipid accumulation, and, at the higher dietary levels, adenofibrosis. Ultrastructural changes of the livers of exposed animals consisted of an increase in smooth endoplasmic reticulum and atypical mitochondria. Lipid vacuoles were occasionally surrounded by concentric membranes. The epithelial component of adenofibrosis consisted of goblet cells and cells that resembled the epithelium which lines the bile ducts. In general, the effect of Aroclor 1254 on the liver was more pronounced than that of Aroclor 1260.read more
Citations
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Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment
TL;DR: Analysis of the results of laboratory animal and wildlife studies suggests that the predictive value of TEQs for PCBs may be both species- and response-dependent because both additive and nonadditive (antagonistic) interactions have been observed with PCB mixtures.
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Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action
TL;DR: The results clearly show that like "dioxin", the PCBs and PBBs elicit their effects through a cytosolic receptor protein which preferentially binds with the toxins which are approximate isostereomers of 2,3,7,8-TCDD.
Toxicological profile for polychlorinated biphenyls (PCBs)
Obaid Faroon,James N. Olson +1 more
TL;DR: A toxicological profile for PCBs, Draft for Public Comment, was released in December 1998 as discussed by the authors, which supercedes any previously released draft or final profile, but no less than once every three years.
Journal ArticleDOI
The toxicity of polychlorinated polycyclic compounds and related chemicals.
TL;DR: The Toxicity of Polychlorinated Polycyclic Compounds and Related Chemicals: Critical Reviews in Toxicology: Vol.
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Expression of hepatic transcription factors during liver development and oval cell differentiation.
TL;DR: The upregulation of the "establishment" factors (HNF1 and -3) may be an important step in oval cell activation and the high levels of these factors in the oval cells and embryonic hepatoblasts further substantiates the similarity between the two cell compartments.
References
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A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
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Polychlorinated biphenyls in the global ecosystem.
TL;DR: Polychlorinated biphenyls are widely dispersed in the global ecosystem, and are powerful inducers of hepatic enzymes which degrade oestradiol, which could account for a large part of the aberration in calcium metabolism which has been observed in many species of birds since the Second World War.
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The acute toxicity of pesticides to rats
TL;DR: A comparison of laboratory results and use experience indicates that there is a much closer relationship between dermal LD 50 values and the occurrence of occupational poisoning than between oral LD50 values and occupational poisoning.
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Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls.
TL;DR: It is concluded that evaluation of animal tests on PCB is made extremely difficult by the presence of chlorinated dibenzofurans in some commercial PCB preparations.