Peter Nagy

TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.

TL;DR: Increased levels of circulating TGF-beta 1 induced progressive renal disease that was characterized by mesangial expansion, accumulation of glomerular immune deposits and matrix proteins, and interstitial fibrosis in this transgenic mouse model, suggesting that chronically elevated circulating levels of TGF -beta 1 induce progressive glomerulosclerosis.

TL;DR: The precursor-product relationship between oval cells and basophilic hepatocytes has been established and the first demonstration of the transfer of radiolabeled thymidine from oval cells to newly formed hepatocytes in vivo is demonstrated.

TL;DR: The simultaneous expression of TGF-beta 1 and procollagen genes in mesenchymal cells, including Desmin-positive perisinusoidal cells, during hepatic fibrosis suggests the possibility that TGF -beta 1 may have an important role in the production of fibrosis.

TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.