Journal ArticleDOI
Mortality update of workers exposed to acrylonitrile in The Netherlands.
Gerard M H Swaen,Louis J. N. Bloemen,Jan Twisk,Theo Scheffers,J. J. M. Slangen,James J. Collins,Wil F. J. P. Ten Berge +6 more
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TLDR
The notion that occupational exposures to acrylonitrile that have occurred in the past have not noticeably increased workers’ cancer mortality rates further supports the notion that occupation-related cancer deaths are not noticeably higher.Abstract:
To study the possible carcinogenic effects of acrylonitrile, we updated the follow up of a cohort of 2842 acrylonitrile workers. The comparison group consisted of 3961 workers from a nitrogen fixation plant. Industrial hygiene assessments quantified past exposure to acrylonitrile, 8-hour averages as well as peak exposure, the use of personal protective equipment, and exposure to other potential carcinogenic agents. Standardized mortality ratios were calculated to adjust for the effect of age distribution, length of follow up, and temporal changes in background mortality rates. Cumulative dose-effect relations were determined for 3 exposure categories and 3 latency periods. The results show that no cancer excess seems related to exposure to acrylonitrile. This additional follow up of a cohort of 2842 workers exposed to acrylonitrile further supports the notion that occupational exposures to acrylonitrile that have occurred in the past have not noticeably increased workers' cancer mortality rates.read more
Citations
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Acrylonitrile and cancer: a review of the epidemiology.
TL;DR: In this review the four most informative cohort studies are evaluated and it is apparent that the results do not support a causal relationship between AN and all cancers or any specific type of cancer.
Journal ArticleDOI
Renal cancer risk and occupational exposure to polycyclic aromatic hydrocarbons and plastics.
Sara Karami,Paolo Boffetta,Paolo Boffetta,Paul Brennan,Patricia A. Stewart,David Zaridze,Vsevolod Matveev,Vladimir Janout,Helena Kollárová,Vladimir Bencko,Marie Navratilova,Neonila Szeszenia-Dabrowska,Dana Mates,Jan P. Gromiec,Roman Sobotka,Wong Ho Chow,Nathaniel Rothman,Lee E. Moore +17 more
TL;DR: Results indicate a possible association between occupational styrene and acrylonitrile exposure and RCC risk, and additional studies are needed to replicate findings, as this is the first time these associations have been reported and they may be due to chance.
Journal ArticleDOI
Occupational Risk Factors for Prostate Cancer: A Meta-analysis
Srmena Krstev,Anders Knutsson +1 more
TL;DR: The literature review supports a causal association for a few of the previously suggested factors that have been suggested to cause prostate cancer.
Journal ArticleDOI
Provisional Advisory Levels (PALs) for acrylonitrile
TL;DR: Application of Provisional Advisory Level (PAL) protocols was performed for acrylonitrile, as experimental data permitted, and the animal experimental data set for this chemical was robust for inhalation and oral studies, with the exception of appropriate data for inhalations 30-day, 90- day, and 2-year PAL 3 values.
Journal ArticleDOI
Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity
Christopher R. Kirman,Michael L. Gargas,Gary M. Marsh,Dale E. Strother,James E. Klaunig,James J. Collins,Randy Deskin +6 more
TL;DR: The weight-of-evidence supports the use of a nonlinear extrapolation for the cancer dose-response assessment of acrylonitrile (AN) and a quantitative comparison of the epidemiology exposure-response data to the rat brain tumor data in terms of internal dose adds to the confidence in the non linear extrapolation.
References
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Book
Statistics with confidence
TL;DR: Uncertainty and Psychological Research Variables and Measurement Exploring, Describing, Displaying and Summarizing Research Design and Probability Sampling Distributions and Confidence Intervals Statistical Models and Significance Tests Predicting a Quantitative Variable from a Categorical Variable The t Test and Analysis of Variance Quantitative Predictors Regression and Correlation Predicting categorical Variables Contingency Tables and Chi-square More than Two Variables A Peek at Multivariate Analysis Putting Statistics into Perspective
Journal ArticleDOI
Mortality patterns among workers exposed to acrylamide.
TL;DR: Analysis of mortality in a cohort of 8854 men examined from 1925 to 1983 showed no trend of increased risk of mortality from several cancer sites, and the hypothesis that acrylamide is a human carcinogen is supported.
Journal Article
Mortality of Industrial Workers Exposed to Acrylonitrile
Aaron Blair,Patricia A. Stewart,Dennis D. Zaebst,Linda M. Pottern,John N. Zey,Thomas F. Bloom,Barry A. Miller,Elizabeth M. Ward,Jay H. Lubin +8 more
TL;DR: Exposure to acrylonitrile at the levels studied is not associated with an increased relative risk for most cancers of a priori interest, and analyses of exposure-response do not provide strong or consistent evidence for a causal association.
Journal ArticleDOI
Mortality of United Kingdom acrylonitrile polymerisation workers.
J B Werner,J T Carter +1 more
TL;DR: The results are not conclusive and neither add to nor detract from existing suspicions that acrylonitrile is a human carcinogen but indicate the necessity for the continuing surveillance of the exposed population in the United Kingdom.
Journal Article
Mortality update of workers exposed to acrylonitrile in The Netherlands.
G M H Swaen,Louis J. N. Bloemen,J. Twisk,Theo Scheffers,J. J. M. Slangen,James J. Collins,ten Berge Wf,Ferd Sturmans +7 more
TL;DR: A retrospective cohort study investigating the cause-specific mortality patterns of 2842 workers occupationally exposed to acrylonitrile for at least 6 months before 1 July 1979 was updated as mentioned in this paper.