Journal ArticleDOI
Motor responses of autoimmune NZB/B1NJ and C57BL/6Nnia mice to arecoline and nicotine.
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TLDR
It is suggested that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.Abstract:
In 11-13 month C57BL/6Nnia mice, arecoline produced a dose-dependent decrease in motor activity at doses of 0.64-2.5 mg/kg, whereas at doses of 5.0-20.0 mg/kg arecoline produced a dose-dependent increase in motor activity. In marked contrast, age-matched NZB/B1NJ (New Zealand Black) mice failed to exhibit the first phase of the response, but showed a greater dose-dependent increase in motor activity following the doses of 10 and 20 mg/kg. Nicotine, 0.64-2.5 mg/kg, produced a dose-dependent decrease in motor activity in both strains. The effects of arecoline and nicotine were antagonized by scopolamine (2.5 mg/kg) and mecamylamine (1.0 mg/kg), respectively. These findings suggest that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.read more
Citations
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Journal ArticleDOI
Age differences in acquisition and retention of one-way avoidance learning in C57BL/6NNia and autoimmune mice
TL;DR: It is suggested that while 48-h retention performance deficits were most related to chronological age, avoidance acquisition deficits were related to development of autoimmunity.
Journal ArticleDOI
Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence
TL;DR: Results are consistent with the hypothesis that imbalanced neurotransmitter regulation of the hypothalamus-pituitary axis plays an important role in the etiology of behavioral dysfunction induced by systemic autoimmune disease.
Journal ArticleDOI
Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice
Harbans Lal,Michael J. Forster +1 more
TL;DR: It is suggested that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.
Journal ArticleDOI
Autoimmunity and age-associated cognitive decline.
Harbans Lal,Michael J. Forster +1 more
TL;DR: The immune system could be an important target for development of intervention strategies aimed at extending the intellectually competent period of life, and mice in which autoimmunity is accelerated may be useful as models for the development of such interventions.
Journal ArticleDOI
Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease
TL;DR: It is suggested that treatments that delay or prevent age‐related immunological dysfunctions be evaluated for their ability to retard age‐associated cognitive decline.
References
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Book
Statistical Principles in Experimental Design
TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Journal ArticleDOI
Statistical Principles in Experimental Design
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Alzheimer's disease: a disorder of cortical cholinergic innervation
TL;DR: Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.