Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain.
Richard A. D. Carano,Fuhai Li,Katsumi Irie,Karl G. Helmer,Matthew D. Silva,Marc Fisher,Christopher H. Sotak +6 more
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TLDR
A new multispectral (MS) approach is described to characterize cerebral ischemia in a time‐independent fashion and produced an estimate of lesion volume that was highly correlated with postmortem infarct volume, independent of the age of the lesion.Abstract:
A major difficulty in staging and predicting ischemic brain injury by magnetic resonance (MR) imaging is the time-varying nature of the MR parameters within the ischemic lesion. A new multispectral (MS) approach is described to characterize cerebral ischemia in a time-independent fashion. MS analysis of five MR parameters (mean diffusivity, diffusion anisotropy, T2, proton density, and perfusion) was employed to characterize the progression of ischemic lesion in the rat brain following 60 minutes of transient focal ischemia. k-Means (KM) and fuzzy c-means (FCM) classification methods were employed to define the acute and subacute ischemic lesion. KM produced an estimate of lesion volume that was highly correlated with postmortem infarct volume, independent of the age of the lesion. Overall classification rates for KM exceeded FCM at acute and subacute time points as follows: KM, 90.5%, 94.4%, and 95.9%; FCM, 82.4%, 90.6%, and 82.6% (for 45 minutes, 180 minutes, and 24–120 hours post MCAO groups). MS analysis also offers a formal method of combining diffusion and perfusion parameters to provide an estimate of the ischemic penumbra (KM classification rate = 70.3%). J. Magn. Reson. Imaging 2000;12:842–858. © 2000 Wiley-Liss, Inc.read more
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Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review
Yaniv Assaf,Ofer Pasternak +1 more
TL;DR: While DTI offers a powerful tool to study and visualize white matter, it suffers from inherent artifacts and limitations and provides an efficient tool for comprehensive, noninvasive, functional anatomy mapping of the human brain.
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Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia.
Aysan Durukan,Turgut Tatlisumak +1 more
TL;DR: Various rodent animal models, pathogenic mechanisms, and promising therapeutic approaches of ischemic stroke are focused on.
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The role of diffusion tensor imaging in the evaluation of ischemic brain injury - a review.
TL;DR: Water diffusion in brain tissue is affected by the presence of barriers to translational motion such as cell membranes and myelin fibers and the measured water apparent diffusion coefficient value is frequently anisotropic and varies depending upon the orientation of restricting barriers relative to the diffusion‐sensitive‐gradient direction.
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Diffusion tensor imaging in schizophrenia.
Richard A A Kanaan,Jin Suh Kim,Walter E. Kaufmann,Walter E. Kaufmann,Godfrey D. Pearlson,Godfrey D. Pearlson,Gareth J. Barker,Philip McGuire +7 more
TL;DR: Diffusion tensor imaging has yet to provide consistent findings of white matter abnormalities in schizophrenia, and its potential as a means of examining anatomical connectivity may be realized with the study of larger, more homogenous groups of subjects and with ongoing improvements in image analysis.
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Nuclear magnetic resonance (NMR) measurement of the apparent diffusion coefficient (ADC) of tissue water and its relationship to cell volume changes in pathological states.
TL;DR: The implication is that acute neurological disorders that exhibit electrical conductivity changes should also exhibit ADC changes that are detectable by DWI, and results indicate that reduced ADC values are associated with reductions in the extracellular volume fraction and increased Extracellular tortuosity.
References
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Numerical recipes in C
TL;DR: The Diskette v 2.06, 3.5''[1.44M] for IBM PC, PS/2 and compatibles [DOS] Reference Record created on 2004-09-07, modified on 2016-08-08.
Journal ArticleDOI
Pattern Classification and Scene Analysis.
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Pattern classification and scene analysis
Richard O. Duda,Peter E. Hart +1 more
TL;DR: In this article, a unified, comprehensive and up-to-date treatment of both statistical and descriptive methods for pattern recognition is provided, including Bayesian decision theory, supervised and unsupervised learning, nonparametric techniques, discriminant analysis, clustering, preprosessing of pictorial data, spatial filtering, shape description techniques, perspective transformations, projective invariants, linguistic procedures, and artificial intelligence techniques for scene analysis.
Journal ArticleDOI
Spin diffusion measurements : spin echoes in the presence of a time-dependent field gradient
E. O. Stejskal,J. E. Tanner +1 more
TL;DR: In this article, a derivation of the effect of a time-dependent magnetic field gradient on the spin-echo experiment, particularly in the presence of spin diffusion, is given.
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