Institution
National Center for Research Resources
About: National Center for Research Resources is a based out in . It is known for research contribution in the topics: Wavelet transform & Pharmacokinetics. The organization has 234 authors who have published 227 publications receiving 22994 citations. The organization is also known as: NCRR.
Topics: Wavelet transform, Pharmacokinetics, Fast wavelet transform, Translational science, Imaging phantom
Papers published on a yearly basis
Papers
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TL;DR: Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff.
5,641 citations
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TL;DR: Laser capture microdissection under direct microscopic visualization permits rapid one-step procurement of selected human cell populations from a section of complex, heterogeneous tissue.
Abstract: Laser capture microdissection (LCM) under direct microscopic visualization permits rapid one-step procurement of selected human cell populations from a section of complex, heterogeneous tissue. In this technique, a transparent thermoplastic film (ethylene vinyl acetate polymer) is applied to the surface of the tissue section on a standard glass histopathology slide; a carbon dioxide laser pulse then specifically activates the film above the cells of interest. Strong focal adhesion allows selective procurement of the targeted cells. Multiple examples of LCM transfer and tissue analysis, including polymerase chain reaction amplification of DNA and RNA, and enzyme recovery from transferred tissue are demonstrated.
2,371 citations
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TL;DR: Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder.
1,467 citations
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TL;DR: Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage, and H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
Abstract: Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clarify the physiological role of H2AX, we targeted H2AX in mice. Although H2AX is not essential for irradiation-induced cell-cycle checkpoints, H2AX −/− mice were radiation sensitive, growth retarded, and immune deficient, and mutant males were infertile. These pleiotropic phenotypes were associated with chromosomal instability, repair defects, and impaired recruitment of Nbs1, 53bp1, and Brca1, but not Rad51, to irradiation-induced foci. Thus, H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
1,387 citations
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TL;DR: The phantom results demonstrate that perfusion levels comparable with those found in vivo have easily observable and reproducible effects on signal amplitude that are consistent with previous IVIM theory.
Abstract: The recently established single-shot technique of echo-planar imaging of intravoxel incoherent motion (IVIM) for determining and imaging the variations of microscopic motions of water has been applied to studies of water perfusion in phantoms and to in vivo studies of diffusion and perfusion in cat and human brains. The phantom results demonstrate that perfusion levels comparable with those found in vivo have easily observable and reproducible effects on signal amplitude that are consistent with previous IVIM theory. Reliable measurements of the diffusion coefficient in various types of brain tissue have been obtained. The results for white matter are consistent with the existence of anisotropic diffusion in oriented bundles of myelinated nerve fibers. The results for gray matter can be fitted to the IVIM theory and suggest a value of up to 14% for the fraction of the signal contributed by randomly perfusing fluid in normal cerebral cortex.
577 citations
Authors
Showing all 234 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jay H. Hoofnagle | 121 | 434 | 57008 |
Ettore Appella | 116 | 509 | 57926 |
Robert Turner | 111 | 557 | 58744 |
Günther Deuschl | 109 | 706 | 46371 |
Harvey I. Pass | 108 | 644 | 47456 |
Michael Unser | 102 | 862 | 49220 |
Philip A. Pizzo | 83 | 366 | 29870 |
Ingrid Daubechies | 73 | 266 | 83887 |
Carl W. Anderson | 71 | 137 | 19680 |
Peter J. Basser | 69 | 314 | 42777 |
Richard B.S. Roden | 68 | 202 | 15975 |
Chrit T. W. Moonen | 68 | 299 | 15364 |
Thomas F. DeLaney | 63 | 344 | 15373 |
James J. Pekar | 63 | 153 | 20167 |
Kazuyasu Sakaguchi | 57 | 170 | 18908 |