Journal ArticleDOI
Muscular dystrophy in the mouse caused by an allele at the dy-locus.
Hans Meier,Janice L. Southard +1 more
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TLDR
A progressive hereditary myopathy of mice caused by a second allele, dy 2J, at the dy -locus is described, which is milder than the original muscular dystrophy, and both afflicted males and females have bred.About:
This article is published in Life Sciences.The article was published on 1970-02-08. It has received 136 citations till now. The article focuses on the topics: Muscular dystrophy & Myopathy.read more
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Journal ArticleDOI
Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene.
TL;DR: The classic murine muscular dystrophy strain, dy, was first described almost 40 years ago and the molecular basis of an allele of dy, called dy 2J, is identified by detecting a mutation in the laminin α2 chain gene — the first identified mutation in lamin in-2.
Journal ArticleDOI
Invited review: myoblast transfer: a possible therapy for inherited myopathies?
TL;DR: The data establish the principle that such grafts effect an alteration of the genetic constitution and phenotype of skeletal muscle and, therefore, might be used to alleviate recessively inherited myopathies.
Journal ArticleDOI
Merosin-deficient Congenital Muscular Dystrophy Partial Genetic Correction in Two Mouse Models
TL;DR: The results indicate that the absence of merosin in tissues other than the muscle, such as nervous tissue, is a critical component of MCMD, and future gene therapies of human MCMD and perhaps of other forms of muscular dystrophy may require restoration of the defective gene product in multiple tissues.
Journal ArticleDOI
Linkage of Familial Dilated Cardiomyopathy with Conduction Defect and Muscular Dystrophy to Chromosome 6q23
TL;DR: An autosomal dominant disorder involving dilated cardiomyopathy, cardiac conduction-system disease, and adult-onset limb-girdle muscular dystrophy is characterized, identifying FDC-CDM as a genetically distinct disease.
Journal ArticleDOI
Mechanosensitive ion channels in skeletal muscle from normal and dystrophic mice.
TL;DR: Histological examination of the flexor digitorum brevis fibres from mdx mice showed no evidence of myonecrosis or regenerating fibres, suggesting that the elevated channel activity in dystrophin‐deficient muscle precedes the onset of fibre degeneration.
References
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Journal ArticleDOI
Histopathology of hereditary, progressive muscular dystrophy in inbred strain 129 mice.
William T. West,Edwin D. Murphy +1 more
Journal Article
A revision of the standardized genetic nomenclature for mice.
Journal ArticleDOI
Part I Hereditary Primary Myopathies in Laboratory Animals: HEREDITARY MOUSE MUSCULAR DYSTROPHY WITH PARTICULAR EMPHASIS ON PATHOGENESIS AND ATTEMPTS AT THERAPY*
TL;DR: It appears that the onset of dystrophy is earlier in females than males, while the severity of symptoms seems to progress more rapidly in males than in females, and the best animals appear in the F1 hybrid population which segregates for especially long-lived, vigorous dystrophic animals which are essentially identical to their normal littermates except for the genes at the dy locus.
Journal ArticleDOI
Artificial insemination of dystrophic mice with mixtures of spermatozoa.
TL;DR: Dystrophia muscularis, symbol dy, is transmitted as an autosomal recessive and is linked to Steel (Sl) and Ames waltzer (av) in linkage group IV3–5.
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Abnormalities of peripheral nerves in murine muscular dystrophy.
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