Journal ArticleDOI
Mutagenicity of inhaled diethyl sulphate vapour in Drosophila melanogaster and its implications for the utility of the system for screening air pullutants
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This article is published in Mutation Research\/genetic Toxicology.The article was published on 1979-02-01. It has received 9 citations till now.read more
Citations
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Journal ArticleDOI
Genetic effects of dimethyl sulfate, diethyl sulfate, and related compounds.
TL;DR: Most data are consistent with these agents acting primarily as base-pair substitution mutagens, and strong specificity for G.C to A.T transitions has been reported in some systems but has not been clearly supported in some others.
Journal ArticleDOI
Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
R. Valencia,Seymour Abrahamson,William R. Lee,E.S. Von Halle,Ronny C. Woodruff,Friedrich E. Würgler,Stanley Zimmering +6 more
TL;DR: The term "chromosome mutations" refers to alterations of chromosome structure (reciprocal, heritable translocations), of chromosome number (loss or gain of a whole chromosome), or of chromosome content (loss of a part of a chromosome) Chromosome mutation may result from chromosome breakage (clastogenesis) and its consequences or from disruption of chromosome behavior during cell division (nondisjunction) as mentioned in this paper.
Journal ArticleDOI
Current status of aneuploidy testing in drosophila
TL;DR: Based on the literature on file at EMIC, 181 papers contained material on aneuploidy testing, and no reliable data exists regarding results in other tests for the remaining 10 compounds; accordingly, the answer to the question awaits further work.
Journal ArticleDOI
Drosophila melanogaster p-glycoprotein: a membrane detoxification system toward polycyclic aromatic hydrocarbon pollutants.
Christel Vache,Olivier Camares,Fabienne De Graeve,Bernard Dastugue,Annie Meiniel,Chantal Vaury,Serge Pellier,Eva Leoz-Garziandia,Mahchid Bamdad +8 more
TL;DR: Flow cytometry experiments using Drosophila Sl2 cells in the presence of PAHs and target P‐gp drug compounds revealed that Drosophile P‐GP acted as an efflux detoxification pump and showed a dose‐dependent increase response.
Journal ArticleDOI
Aneuploidy in Drosophila, II. Further validation of the FIX and ZESTE genetic test systems employing female Drosophila melanogaster.
TL;DR: Comparison of the induced rates of aneuploidy i indicates that these can exhibit departures from simple additivity to the spontaneous rates: induced rates in the ZESTE system are generally higher and more variable than those from FIX.
References
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Book
The Genetics and biology of Drosophila
TL;DR: This is the first attempt since 1925 to publish a comprehensive account of the biology and genetics of Drosophila and it aims to collate the dauntingly large literature on the subject and to make more accessible the private language ot the Dosophilist.
Book
Chemical Mutagens: Principles and Methods for Their Detection
TL;DR: This book discusses the development and validation of short-term assays designed to detect the mutagenic effects of environmental chemicals, and the detection of mutagens in human feces as an approach to the discovery of causes of colon cancer.
Book ChapterDOI
The Function of Drosophila in Genetic Toxicology Testing
E. Vogel,F. H. Sobels +1 more
TL;DR: Recent findings suggest a striking overlap between the mutagenic and carcinogenic potential of chemicals that a distinction between the two tends to become an artificial one.
Journal ArticleDOI
The advantages of drosophila for mutation studies
TL;DR: Observations on modifications and specificities in Drosophila, show at least that a particular treatment can be modified, and this may then be followed up in mammalian cells, which may provide guidance on the kind of questions that should be looked for in more laborious systems.
Related Papers (5)
The mutagenic activity of diethyl sulphate in Drosophila melanogaster
M. Pelecanos,T. Alderson +1 more