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Myeloid-associated differentiation antigens on stem cells and their progeny identified by monoclonal antibodies

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TLDR
A series of monoclonal antibodies that reacts with myeloids-associated determinants on committed myeloid stem cells and their progeny are generated and potential applications of these antibodies to studies of normal and malignant hematopoiesis are discussed.
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This article is published in Blood.The article was published on 1983-07-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Myeloid stem cell & Monoclonal antibody.

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Approval Summary: Gemtuzumab Ozogamicin in Relapsed Acute Myeloid Leukemia

TL;DR: Tolerability and ease of administration may be improved compared with conventional chemotherapy, except for hepatotoxicity, with 31% of patients exhibiting abnormal liver enzymes, and the reduction of leukocyte counts to below 30,000/ml is recommended prior to treatment.
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Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

TL;DR: These constructs represent the first of a new generation of single gene multidomain chimeric receptors capable of mediating both primary and costimulatory signaling specifically from a single extracellular recognition event.
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Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain.

TL;DR: This type of chimeric receptor may now be used to discover the most potent combination of costimulatory signals that will improve current immunotherapeutic strategies.
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Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate.

TL;DR: In a dose escalation study, 40 patients with relapsed or refractory CD33 + acute myeloid leukemia (AML) were treated with an immunoconjugate (CMA-676) consisting of humanized anti-CD33 antibody linked to the potent antitumor antibiotic calicheamicin this paper.
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A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells

TL;DR: Anti-MY9 may be a valuable reagent for the purification of hematopoietic colony-forming cells and for the diagnosis of myeloid-lineage leukemias.
References
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Journal ArticleDOI

Continuous cultures of fused cells secreting antibody of predefined specificity

TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.
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Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

TL;DR: The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.
Journal Article

A monoclonal antibody reactive with human peripheral blood monocytes.

TL;DR: Findings provided additional support for the notion that OKM1 was reactive with monocytes, and appeared to define two distinct populations of monocytes; an adherent population of large cells bearing surface Ia determinants and a nonadherent population of small, Ia-negative cells.
Journal Article

Antigens on human monocytes identified by monoclonal antibodies.

TL;DR: Results indicate that Mo1 and Mo2 are unique antigens that may represent distinct stages of late monocyte-granulocyte differentiation.
Journal ArticleDOI

Expression of myeloid differentiation antigens on normal and malignant myeloid cells.

TL;DR: A series of monoclonal antibodies have been characterized that define four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells derived from a fusion of the NS-1 plasmacytoma cell line with splenocytes from a mouse immunized with human acute myelomonocytic leukemia cells.
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