Journal ArticleDOI
Myeloid karyotype and the malignant phase of chronic granulocytic leukaemia.
TLDR
During the course of a 30 month study period, 26 patients with typical chronic granulocytic leukaemia (CGL) developed karyotype abnormalities in addition to the Philadelphia (Ph1) chromosome.Abstract:
During the course of a 30 month study period, 26 patients with typical chronic granulocytic leukaemia (CGL) developed karyotype abnormalities in addition to the Philadelphia (Ph1) chromosome. All cases had received at least 14 months continuous low dose busulphan, and the chromosome changes were found before clinical transformation in six patients and at the time this occurred in 20.
Survival following the discovery of these additional abnormalities was short, with a median of 11 weeks for the whole group. Trisomy 8 was the commonest additional chromosome abnormality, but no one karyotype change was clearly associated with shorter survival than another.
23 of the 26 have died as a direct result of their disease, forming part of a total of 40 deaths from typical CGL encountered during the study period where karyotype analyses were performed during the terminal stages of the disease. Of these 40, only two (5%) patients showed no chromosome abnormalities extra to the Ph1 prior to death. (The 17 non-study patients who died were similar in all respects to the 23 from the study group, but had no prior chromosome studies performed during the chronic phase of the disease.)
It is suggested that an expanding aneuploid or pseudodiploid clone arising from the leukaemic cells during the benign phase of CGL can be used to mark the sometimes ill-defined onset of the malignant phase in all but a small proportion of cases.read more
Citations
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Journal ArticleDOI
Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia
TL;DR: It is suggested that all these aberrations, occurring in >5% of CML with secondary changes, should be denoted major route abnormalities, except for slightly lower frequencies of the most common changes in the latter group.
Journal ArticleDOI
Clustering of aberrations to specific chromosomes in human neoplasms. IV. A survey of 1,871 cases.
Felix Mitelman,Göran Levan +1 more
Journal ArticleDOI
Clustering of aberrations to specific chromosomes in human neoplasms
Göran Levan,Felix Mitelman +1 more
TL;DR: One main conclusion of the paper is that the aberrations of the selectively involved chromosomes influence cancer development because of the genes they carry.
Journal ArticleDOI
Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CML
TL;DR: The chromosomal changes, in addition to the Ph1, accompanying unusual Ph1 translocations in CML are not different from those seen in cases with the standard type of Ph 1 translocation.
References
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Journal ArticleDOI
Clinical Implications of Cytogenetic Variants in Chronic Myelocytic Leukemia (CML)
TL;DR: The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.
Journal ArticleDOI
Characteristics of blast crisis in chronic granulocytic leukemia.
TL;DR: Hmatologic criteria for the diagnosis of blast crisis are presented and the importance of extramedullary leukemia in heralding the onset of blastrisis is emphasized.
Journal ArticleDOI
The cytogenetics of chronic granulocytic leukaemia.
TL;DR: In patients who present with acute leukaemia with the Ph1 chromosome, recent advances in immunological techniques for distinguishing different cytological types of blast cells have provided insight into the relationship of the Ph 1 chromosome to the pathogenesis of the disease.