Journal ArticleDOI
N-methoxy-n-methylamides as effective acylating agents
Steven Nahm,Steven M. Weinreb +1 more
TLDR
Readily preparable N-methoxy-N-methylamides couple in good yields with Grignard and organolithium reagents to produce ketones, and are reduced with hydrides to afford aldehydes.About:
This article is published in Tetrahedron Letters.The article was published on 1981-01-01. It has received 1611 citations till now.read more
Citations
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The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
TL;DR: The reaction types used in the pursuit of novel drug candidates are analyzed to evaluate their frequency of occurrence, alongside other factors such as drug likeness, chirality, and the number of steps to each derivative.
Journal ArticleDOI
1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
Journal ArticleDOI
Carboxylic acids as substrates in homogeneous catalysis.
TL;DR: This review provides an overview of interesting catalytic transformations of carboxylic acids and a number of derivatives accessible from them in situ to provide an invitation to complement, refine, and use these new methods in organic synthesis.
Journal ArticleDOI
Conversion of amides to esters by the nickel-catalysed activation of amide C-N bonds
Liana Hie,Noah F. Fine Nathel,Tejas K. Shah,Emma L. Baker,Xin Hong,Yun-Fang Yang,Peng Liu,Kendall N. Houk,Neil K. Garg +8 more
TL;DR: It is demonstrated that amide carbon–nitrogen bonds can be activated and cleaved using nickel catalysts and is expected to lead to the further use of amides in the construction of carbon–heteroatom or carbon–carbon bonds using non-precious-metal catalysis.
Journal ArticleDOI
New hybrid transition state analog inhibitors of HIV protease with peripheric C2-symmetry
TL;DR: In this article, a hybrid transition state analogs, a combination of phosphinic acid-and hydroxy-methylene-type inhibitors of HIV protease, was proposed, placed in a peripheric C 2 -symmetrical environment.
References
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Journal ArticleDOI
Reaction of S-(2-pyridyl) thioates with Grignard reagents. Convenient method for the preparation of ketones
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Relative reactivity and structures of benzoyltrimethylhydrazine and 1-benzoyl-2-methylpyrazolidine
Journal ArticleDOI
Conjugate Addition of Alkyllithium Reagents to α,β-Unsaturated N, N',N'-Trimethylhydrazides
Spencer Knapp,John Calienni +1 more
TL;DR: The site of nucleophilic attack by an alkyllithium reagent upon an α,β-unsaturated carbonyl compound is governed by, among other factors, the nature of the group attached to the carbonyls.
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