Journal ArticleDOI
Nanodiamond-Based Composite Structures for Biomedical Imaging and Drug Delivery.
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TLDR
A particular focus of the review is core/shell structures of nanodiamond surrounded by porous silica shells, which demonstrate a remarkable increase in drug loading efficiency; as well as nanod diamonds decorated with carbon dots, which have excellent potential as bioimaging probes.Abstract:
Nanodiamond particles are widely recognized candidates for biomedical applications due to their excellent biocompatibility, bright photoluminescence based on color centers and outstanding photostability. Recently, more complex architectures with a nanodiamond core and an external shell or nanostructure which provides synergistic benefits have been developed, and their feasibility for biomedical applications has been demonstrated. This review is aimed at summarizing recent achievements in the fabrication and functional demonstrations of nanodiamond-based composite structures, along with critical considerations that should be taken into account in the design of such structures from a biomedical point of view. A particular focus of the review is core/shell structures of nanodiamond surrounded by porous silica shells, which demonstrate a remarkable increase in drug loading efficiency; as well as nanodiamonds decorated with carbon dots, which have excellent potential as bioimaging probes. Other combinations are also considered, relying on the discussed inherent properties of the inorganic materials being integrated in a way to advance inorganic nanomedicine in the quest for better health-related nanotechnology.read more
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Journal ArticleDOI
Carbon-Based Nanomaterials for Delivery of Biologicals and Therapeutics: A Cutting-Edge Technology
Alok Mahor,Prem Singh,Peeyush Bharadwaj,Neeraj Sharma,Surabhi Yadav,Jessica M. Rosenholm,Kuldeep K. Bansal +6 more
TL;DR: A review of carbon-based nanomaterials (CNMs) can be found in this article, where the authors focus on the recent advances in various types of CNMs, their fabrication techniques, and their application in the delivery of therapeutics both in vitro and in vivo.
Journal ArticleDOI
Pilot study on biocompatibility of fluorescent nanodiamond-(NV)-Z~800 particles in rats: safety, pharmacokinetics, and bio-distribution (part III)
Frank C. Barone,Cezary Marcinkiewicz,Jie Li,Mark Sternberg,Peter I. Lelkes,Dmitriy A. Dikin,Peter J. Bergold,Jonathan A. Gerstenhaber,Giora Z. Feuerstein +8 more
TL;DR: Systemic exposure of rats to a single high dose of FDNP-(NV)-Z~800 (60 mg/kg) appeared to be safe and well tolerated over at least 2 weeks, and data suggest that FNDP-(NV) should proceed to preclinical development in the near future.
Journal ArticleDOI
Fluorescence microscopy for visualizing single-molecule protein dynamics
TL;DR: Quantitative, high-resolution single-molecule studies will help establish an understanding of protein dynamics and complex biomolecular systems and will continue to improve regarding the photostability of fluorophores.
Journal ArticleDOI
The use of nanocluster polyoxometalates in the bioactive substance delivery systems
TL;DR: In this article, a review of nanocluster polyoxometalate-based systems for transdermal iontophoretic transport is presented, and the problems of the transfer processes modeling are considered.
Journal ArticleDOI
Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use
A. A. Ostroushko,K.V. Grzhegorzhevskii,S. Yu. Medvedeva,I. F. Gette,M. O. Tonkushina,I. D. Gagarin,Irina G. Danilova +6 more
TL;DR: In this article, the physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs) are discussed.
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