Journal ArticleDOI
Nanodiamond-Based Composite Structures for Biomedical Imaging and Drug Delivery.
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TLDR
A particular focus of the review is core/shell structures of nanodiamond surrounded by porous silica shells, which demonstrate a remarkable increase in drug loading efficiency; as well as nanod diamonds decorated with carbon dots, which have excellent potential as bioimaging probes.Abstract:
Nanodiamond particles are widely recognized candidates for biomedical applications due to their excellent biocompatibility, bright photoluminescence based on color centers and outstanding photostability. Recently, more complex architectures with a nanodiamond core and an external shell or nanostructure which provides synergistic benefits have been developed, and their feasibility for biomedical applications has been demonstrated. This review is aimed at summarizing recent achievements in the fabrication and functional demonstrations of nanodiamond-based composite structures, along with critical considerations that should be taken into account in the design of such structures from a biomedical point of view. A particular focus of the review is core/shell structures of nanodiamond surrounded by porous silica shells, which demonstrate a remarkable increase in drug loading efficiency; as well as nanodiamonds decorated with carbon dots, which have excellent potential as bioimaging probes. Other combinations are also considered, relying on the discussed inherent properties of the inorganic materials being integrated in a way to advance inorganic nanomedicine in the quest for better health-related nanotechnology.read more
Citations
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Journal ArticleDOI
Nanocrystalline diamond produced by direct current micro-plasma: Investigation of growth dynamics
Federica Inzoli,David Dellasega,Valeria Russo,R. Caniello,Claudia Conti,Francesco Ghezzi,Matteo Passoni +6 more
TL;DR: In this paper, the growth dynamics of nanocrystalline diamond, deposited on molybdenum and silicon substrates with a direct-current microplasma device, is experimentally investigated.
Amalgamation of Nanodiamond and Epoxy
TL;DR: In this article, the authors have shown that large surface to volume ratio of nanodiamond particles results in dramatic increase in volume of inter-phase, i.e., polymer volume which is close enough to nanobiamond.
Journal ArticleDOI
Adsorption of DNA Nitrogenous Bases on Nanodiamond Particles: Theory and Experiment
Kirill Laptinskiy,Ekaterina N. Vervald,A. N. Bokarev,Sergey A. Burikov,Marco D. Torelli,Olga Shenderova,I. L. Plastun,Tatiana A. Dolenko +7 more
TL;DR: In this paper, the authors investigated the efficiency of adsorption of nucleic acid nitrogenous bases (NBs) on carboxylated detonation nanodiamond (DND)-COOH particles in aqueous media at pH = 7.4-7.6 and pH = 13.4.
Journal ArticleDOI
Monitoring of nanodiamonds in human urine using artificial neural networks
Kirill Laptinskiy,Sergey A. Burikov,Sergey Dolenko,Alexander Efitorov,Alexander Efitorov,Olga Sarmanova,Olga Shenderova,Igor I. Vlasov,Igor I. Vlasov,Tatiana A. Dolenko,Tatiana A. Dolenko +10 more
TL;DR: In this paper, the results of application of elaborated methods for monitoring of nanodiamonds in human urine using fluorescence spectroscopy were presented, where high efficiency of artificial neural networks applied for recognition and estimation of the concentration of nanodes in urine with a strong autofluorescence background is demonstrated.
Journal ArticleDOI
Carboxylated nanodiamonds can be used as negative reference in in vitro nanogenotoxicity studies.
Hélène Moche,Hélène Moche,Vincent Paget,Dany Chevalier,E. Lorge,N. Claude,Hugues Girard,Jean-Charles Arnault,Sylvie Chevillard,Fabrice Nesslany,Fabrice Nesslany +10 more
TL;DR: In vitro genotoxic results reinforce the potential interest of carboxylated NDs for biomedical applications or even as a negative reference nanoparticle in nanotoxicology.
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