Journal ArticleDOI
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update.
Jiahua Cui,Jinping Jia +1 more
TLDR
The review mainly concentrated on recently identified natural products and derivatives as COX-2 inhibitors, the characteristics of their structural core scaffolds, their anti-inflammatory effects, molecular mechanisms for enzymatic inhibition and related structure-activity relationships, and the utilization of these natural remedies in future cancer prevention.Abstract:
COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in the inflammatory process. Different from other family members, COX-2 was barely detectable in normal physiological conditions and highly inducible during the acute inflammatory response of human bodies to injuries or infections. Therefore, the therapeutic utilization of selective COX-2 inhibitors has already been considered as an effective approach for the treatment of inflammation with diminished side effects. Currently, both traditional and newer NSAIDs are the commonly prescribed medications that treat inflammatory diseases by targeting COX-2. However, due to the cardiovascular side-effects of the NSAIDs, finding reasonable alternatives for these frequently prescribed medicines are a hot spot in medicinal chemistry research. Naturallyoccurring compounds have been reported to inhibit COX-2, thereby possessing beneficial effects against inflammation and certain cell injury. The review mainly concentrated on recently identified natural products and derivatives as COX-2 inhibitors, the characteristics of their structural core scaffolds, their anti-inflammatory effects, molecular mechanisms for enzymatic inhibition, and related structure-activity relationships. According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones, and alkaloids. Apart from the anti-inflammatory activities, a few dietary COX-2 inhibitors from nature origin also exhibited chemopreventive effects by targeting COX-2-mediated carcinogenesis. The utilization of these natural remedies in future cancer prevention was also discussed. In all, the survey on the characterized COX-2 inhibitors from natural sources paves the way for the further development of more potent and selective COX-2 inhibitors in the future.read more
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Journal ArticleDOI
Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors.
Jiahua Cui,Jinping Jia +1 more
TL;DR: In this paper, a set of 1,4-naphthoquinones with juglone skeleton were evaluated for the inhibitory efficacy against SARS-CoV-2 Mpro.
Journal ArticleDOI
Lead exposure induced inflammation in bursa of Fabricius of Japanese quail (C. japonica) via NF-κB pathway activation and Wnt/β-catenin signaling inhibition.
TL;DR: In this article, the chronic toxic effects of lead exposure on Bursa of Fabricius (BF) in Japanese quails (C. japonica) and the underlying mechanism of lead immunotoxicity were examined.
Journal ArticleDOI
Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor
TL;DR: In this paper , the authors studied the inhibitory activity of scutellarein and its methylated derivatives against SARS-CoV-2 main protease (Mpro) by the fluorescence resonance energy transfer (FRET) assay.
Journal ArticleDOI
Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies
TL;DR: In this paper, the effects of different pretreatments on MSCs and their secretome, focusing on their immunomodulatory properties, were summarized in order to provide new insights for the therapeutic application of MSC-derived secretome in inflammatory immune diseases.
Journal ArticleDOI
Mogroside V exerts anti-inflammatory effect via MAPK-NF-κB/AP-1 and AMPK-PI3K/Akt/mTOR pathways in ulcerative colitis
Yaping Zhou,Zuomin Hu,Fan Ye,Tianyi Guo,Yi Luo,Wenshen Zhou,Dandan Qin,Yiping Tang,Fuliang Cao,Feijun Luo,Qinlu Lin +10 more
TL;DR: Results indicated that MGV (100 mg/kg/day) supplementation in diet improved the health status of mice, and it exerts anti-inflammatory effect via MAPK-NF-κB/AP-1 and AMPK-PI3K/Akt/mTOR pathways in ulcerative colitis.
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