Book ChapterDOI
Naturally Occurring Plant Coumarins
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7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarin.Abstract:
Over the past 150 years, since Vogel in 1820 isolated the parent oxygen heterocycle, coumarin (1) from Coumarouna odorata = Dipteryx odorata (1), coumarins have been recognized as widely distributed plant products. The vast majority carry an oxygen substituent at C-7; consequently 7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarins. A number of review articles on natural plant coumarins have appeared (154, 302, 344, 420, 525, 541, 548) since the last in this series (153), the most comprehensive, albeit dealing solely with coumarins of the Umbelliferae, being that of Nielsen in 1970 (419).read more
Citations
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Journal ArticleDOI
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
Book ChapterDOI
Coumarins — An Important Class of Phytochemicals
Maria João Matos,Lourdes Santana,Eugenio Uriarte,Orlando A. Abreu,Enrique Molina,Estela Guardado Yordi +5 more
TL;DR: There may be as many as 4,000 different phytochemicals having potential activity against several diseases such as cancer and metabolic or degenerative diseases, but not all are established as essential nutrients.
Journal ArticleDOI
Antibacterial activity of simple coumarins: structural requirements for biological activity.
Oliver Kayser,Herbert Kolodziej +1 more
TL;DR: A combination of these structural features, two methoxy functions and at least one additional phenolic group as reflected by the highly oxygenated coumarins, identify promising candidates with antibacterial broad-spectrum activity.
Journal ArticleDOI
Towards a molecular phylogeny of Apiaceae subfamily Apioideae: Additional information from nuclear ribosomal DNA ITS sequences
Deborah S. Katz-Downie,C.M. Valiejo-Roman,E.I. Terentieva,A. V. Troitsky,Michail G. Pimenov,B. Y. Lee,Stephen R. Downie +6 more
TL;DR: Apioideae were investigated by comparative sequencing of the two internal transcribed spacers of the 18S–26S nuclear ribosomal DNA repeat, clarified the relationships of several genera whose phylogenetic placements have heretofore been problematic.
Journal ArticleDOI
Coumarins as cholinesterase inhibitors: A review.
TL;DR: The studies and development of new compounds for AD treatment are discussed, which objective is to increase the concentration of ACh in the synaptic cleft by the inhibition of cholinesterases.
References
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Book ChapterDOI
Naturally Occurring Coumarins
TL;DR: In this paper, it was shown that apart from coumarin, hydrocoumarin and dicoumarol, all naturally occurring coumarins have an oxygen atom at the 7-position, i.e., they can be regarded as derivatives of umbelliferone.
Journal ArticleDOI
A Furanocoumarin glucoside from stembark of Skimmia japonica
TL;DR: From the stembark of Skimmia japonica the new furanocoumarin glucoside, 2,3,dihydro-9-hydroxy-2-[1-(6-feruloyl)-β-d -glucosyloxy-1-methylethyl]-7H-furo[3,2g] [1]-benzopyran-7-one has been isolated along with three known coumarin compounds as mentioned in this paper.
Journal ArticleDOI
Phenylcoumarins from Ochrocarpus Siamensis
TL;DR: Two new phenylcoumarins, 6butyryl-5,7-dihydroxy-8-(3,3dimethylallyl)-4-phenyleoumarin, were isolated from the flowers of Ochrocarpus siamensis.
Journal ArticleDOI
New glucosides of a 4-hydroxy-5-methylcoumarin and a dihydro-α-pyrone from Gerbera jamesonii hybrida
Journal ArticleDOI
Biologically Active Principles of Crude Drugs. Anti-allergic Principles in "Cnidii monnieri"
Johji Yamahara,Mutsuo Kozuka,Tokunosuke Sawada,Hajime Fujimura,Kimiko Nakano,Toshiaki Tomimatsu,Toshihiro Nohara +6 more
TL;DR: Imperatorine, a coumarin derivative in "Cnidii monnieri"showed anti-allergic activity and its constituents were examined.
Related Papers (5)
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more