Book ChapterDOI
Naturally Occurring Plant Coumarins
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7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarin.Abstract:
Over the past 150 years, since Vogel in 1820 isolated the parent oxygen heterocycle, coumarin (1) from Coumarouna odorata = Dipteryx odorata (1), coumarins have been recognized as widely distributed plant products. The vast majority carry an oxygen substituent at C-7; consequently 7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarins. A number of review articles on natural plant coumarins have appeared (154, 302, 344, 420, 525, 541, 548) since the last in this series (153), the most comprehensive, albeit dealing solely with coumarins of the Umbelliferae, being that of Nielsen in 1970 (419).read more
Citations
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Journal ArticleDOI
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
Book ChapterDOI
Coumarins — An Important Class of Phytochemicals
Maria João Matos,Lourdes Santana,Eugenio Uriarte,Orlando A. Abreu,Enrique Molina,Estela Guardado Yordi +5 more
TL;DR: There may be as many as 4,000 different phytochemicals having potential activity against several diseases such as cancer and metabolic or degenerative diseases, but not all are established as essential nutrients.
Journal ArticleDOI
Antibacterial activity of simple coumarins: structural requirements for biological activity.
Oliver Kayser,Herbert Kolodziej +1 more
TL;DR: A combination of these structural features, two methoxy functions and at least one additional phenolic group as reflected by the highly oxygenated coumarins, identify promising candidates with antibacterial broad-spectrum activity.
Journal ArticleDOI
Towards a molecular phylogeny of Apiaceae subfamily Apioideae: Additional information from nuclear ribosomal DNA ITS sequences
Deborah S. Katz-Downie,C.M. Valiejo-Roman,E.I. Terentieva,A. V. Troitsky,Michail G. Pimenov,B. Y. Lee,Stephen R. Downie +6 more
TL;DR: Apioideae were investigated by comparative sequencing of the two internal transcribed spacers of the 18S–26S nuclear ribosomal DNA repeat, clarified the relationships of several genera whose phylogenetic placements have heretofore been problematic.
Journal ArticleDOI
Coumarins as cholinesterase inhibitors: A review.
TL;DR: The studies and development of new compounds for AD treatment are discussed, which objective is to increase the concentration of ACh in the synaptic cleft by the inhibition of cholinesterases.
References
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Journal ArticleDOI
Total Synthesis of Cleomiscosin A (I), a Coumarinolignoid.
Hitoshi Tanaka,I. Kato,Kazuo Ito +2 more
TL;DR: Synthese a partir de l'O-alkylation en 8 de la fraxetine par le benzyloxy-4 α-bromo methoxy-3 β-oxo benzenepropionate d'ethyle suivie de reduction du cetoester obtenu en diol puis de cyclisation as mentioned in this paper.
Journal ArticleDOI
The structure of alatol
TL;DR: From the roots of Prangos alata Grossh (Prangos biebersteinii Karjag) a new furocoumarin (I), C17H18O6, mp 125-127°C (from benzene), which has been called alatol, has been isolated.
Related Papers (5)
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more