Journal ArticleDOI
Neurodevelopment of Children Exposed in Utero to Antidepressant Drugs
Irena Nulman,Joanne Rovet,Donna E. Stewart,Jacob Wolpin,H. A. Gardner,Jochen G.W. Theis,Nathalie A. Kulin,Gideon Koren +7 more
TLDR
In utero exposure to either tricyclic antidepressant drugs or fluoxetine does not affect global IQ, language development, or behavioral development in preschool children.Abstract:
Background Many women of reproductive age have depression, necessitating therapy with either a tricyclic antidepressant drug or a drug, such as fluoxetine, that inhibits the reuptake of serotonin. Whether these drugs affect fetal neurodevelopment is not known. Methods We studied the children of 80 mothers who had received a tricyclic antidepressant drug during pregnancy, 55 children whose mothers had received fluoxetine during pregnancy, and 84 children whose mothers had not been exposed during pregnancy to any agent known to affect the fetus adversely. The children's global IQ and language development were assessed between 16 and 86 months of postnatal age by age-appropriate Bayley Scales of Infant Development or the McCarthy Scales of Children's Abilities (for IQ) and the Reynell Developmental Language Scales. Results The mean (±SD) global IQ scores were 118±17 in the children of mothers who received a tricyclic antidepressant drug, 117±17 in those whose mothers received fluoxetine, and 115±14 in those ...read more
Citations
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Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission.
Sherryl H. Goodman,Ian H. Gotlib +1 more
TL;DR: A developmentally sensitive, integrative model for understanding children's risk in relation to maternal depression is proposed and three factors that might moderate this risk are considered.
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Journal ArticleDOI
ACOG practice bulletin: Clinical management guidelines for obstetrician-gynecologists
Journal ArticleDOI
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
TL;DR: A critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult is indicated and a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders is suggested.
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Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mice
D. Bengel,Dennis L. Murphy,Anne M. Andrews,Christine Wichems,Douglas Feltner,Armin Heils,Rainald Mössner,Heiner Westphal,Klaus-Peter Lesch +8 more
TL;DR: Data suggest that the presence of a functional 5-HTT is essential for brain 5- HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity.
References
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