Journal ArticleDOI
Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
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TLDR
It is found that the peptide isolated from brain extracts of a peptide amide that was thought to be PYY is a previously uncharacterized peptide, which is designated neuropeptide Y (NPY), which is structurally and biologically similar to vasoactive intestinal peptide (VIP) while PYY shows similarities to pancreatic polypeptides (PP).Abstract:
The C-terminal α-amide structure is a characteristic feature of many biologically active peptides1,2 Using a novel chemical method for the detection of peptide amides3, we have isolated two naturally occurring peptides, peptide HI (PHI) and peptide YY (PYY), from extracts of porcine intestine and have shown that these peptide amides represent previously unknown biologically active peptides4 PHI is structurally and biologically similar to vasoactive intestinal peptide (VIP)5 while PYY shows similarities to pancreatic polypeptide (PP)6 Preliminary studies indicated that PHI and PYY may both be present in brain as well as in intestine4 We report here the isolation from brain extracts of a peptide amide that was thought to be PYY However, we found that the peptide, while having distinct structural and biological similarities to both PYY and PP, is a previously uncharacterized peptide, which we designate neuropeptide Y (NPY)read more
Citations
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Journal ArticleDOI
Prolactin: Structure, Function, and Regulation of Secretion
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Journal ArticleDOI
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Undine E. Lang,Stefan Borgwardt +1 more
TL;DR: The neurodegenerative hypothesis of depression explains decreased hippocampal volumes in depressed patients and changes of neurotrophic support by BDNF, erythropoietin, GDNF, FGF-2, NT3, NGF and growth hormone.
Journal ArticleDOI
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Kazuhiko Tatemoto,Masaki Hosoya,Yugo Habata,Ryo Fujii,Tadao Kakegawa,Min-Xu Zou,Yuji Kawamata,Shoji Fukusumi,Shuji Hinuma,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Masahiko Fujino +12 more
TL;DR: Synthetic peptides derived from the C-terminal amino acid sequence of bovine preproapelin were capable of specifically promoting the acidification rate in the cells expressing the APJ receptor in a range from 10(-7) to 10(-10) M, indicating that apelin is an endogenous ligand for theAPJ receptor.
Journal ArticleDOI
Galanin — a novel biologically active peptide from porcine intestine
TL;DR: It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.
Journal ArticleDOI
Neuropeptide y and human pancreatic polypeptide stimulate feeding behavior in rats
TL;DR: Findings imply that neuropeptide Y, or a closely related pancreatic polypeptides-like neuropePTide, plays an important role in neural regulation of feeding behavior.
References
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Book ChapterDOI
[8] End-group analysis using dansyl chloride.
TL;DR: The very simple procedure recommended for peptides is usually unsuitable for proteins, mainly because of a need to use much more dansyl chloride, and larger volumes.
Journal ArticleDOI
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
Kazuhiko Tatemoto,Viktor Mutt +1 more
TL;DR: A chemical detection system based on fragmentation of peptides in tissue extracts followed by identification of certain of these peptide fragments having distinct chemical features is proposed and several previously unknown peptide amides in porcine upper small intestinal tissues are found.
Journal ArticleDOI
Brain peptides as neurotransmitters.
TL;DR: Peptides, such as cholecystokinin and vasoactive intestinal polypeptide, were known as intestinal hormones and later recognized as brain constituents and may also be central neurotransmitters.