Journal ArticleDOI
New developments in the treatment of ADHD.
Joseph Biederman,Amy F.T. Arnsten,Stephen V. Faraone,Alysa E. Doyle,Thomas J. Spencer,Timothy E. Wilens,Margaret D. Weiss,Steven A. Safren,Larry Culpepper +8 more
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This article is published in The Journal of Clinical Psychiatry.The article was published on 2006-01-16. It has received 27 citations till now. The article focuses on the topics: Atomoxetine hydrochloride & Modafinil.read more
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Journal ArticleDOI
Atomoxetine Modulates Right Inferior Frontal Activation During Inhibitory Control: A Pharmacological Functional Magnetic Resonance Imaging Study
Samuel R. Chamberlain,Adam Hampshire,Ulrich Müller,Katya Rubia,Natalia del Campo,Kevin J. Craig,Ralf Regenthal,John Suckling,Jonathan P. Roiser,Jon E. Grant,Edward T. Bullmore,Trevor W. Robbins,Barbara J. Sahakian +12 more
TL;DR: Results show that atomoxetine exerts its beneficial effects on inhibitory control via modulation of right inferior frontal function, with implications for understanding and treating inhibitory dysfunction of ADHD and other disorders.
Journal ArticleDOI
The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders.
TL;DR: The type of impulsivity measured appears to play a significant role, with the SST and delay discounting providing more consistent effects for dopaminergic drugs, while the CPT and SST show better predictive validity so far for serotonergic and noradrenergic compounds.
Journal ArticleDOI
Translational Approaches to Frontostriatal Dysfunction in Attention-Deficit/Hyperactivity Disorder Using a Computerized Neuropsychological Battery
Samuel R. Chamberlain,Trevor W. Robbins,Sophie Winder-Rhodes,Ulrich Müller,Barbara J. Sahakian,Andrew D. Blackwell,Jennifer H. Barnett +6 more
TL;DR: Substantial cognitive deficits are present in ADHD, which can be remediated somewhat with current medications and which can readily be modeled in experimental animals using back-translational methodology.
Journal ArticleDOI
Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder.
TL;DR: Neurobehavioral, genetic and animal model studies that support the notion that a common, genetically determined failure of response inhibition function is an endophenotype for both ADHD and substance abuse and dependence disorders are described.
Journal ArticleDOI
Relevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder.
TL;DR: Analysis of this network and its dysfunctions suggests that drugs with selective or multiple modes of action on dopamine (DA) and norepinephrine (NE) may have robust therapeutic effects, and this review focuses on NE‐DA interactions as demonstrated in electrophysiological and neurochemical studies.