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Sophie Winder-Rhodes
Researcher at University of Cambridge
Publications - 19
Citations - 2087
Sophie Winder-Rhodes is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dementia & Parkinson's disease. The author has an hindex of 13, co-authored 18 publications receiving 1729 citations. Previous affiliations of Sophie Winder-Rhodes include King's College London.
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Journal ArticleDOI
Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study
Alison J. Yarnall,David P. Breen,Gordon W Duncan,Tien K. Khoo,Shirley Coleman,Michael J. Firbank,Cristina Nombela,Sophie Winder-Rhodes,Jonathan R. Evans,James B. Rowe,Brit Mollenhauer,Niels Kruse,Gavin Hudson,Patrick F. Chinnery,John T. O'Brien,Trevor W. Robbins,Keith Wesnes,David J. Brooks,Roger A. Barker,David J. Burn +19 more
TL;DR: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1–42 and 1–40 levels and future longitudinal studies should enable us to determine those measures predictive of cognitive decline.
Journal ArticleDOI
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandra Beilina,Iakov N. Rudenko,Alice Kaganovich,Laura Civiero,H. Chau,Suneil K. Kalia,Lorraine V. Kalia,Evy Lobbestael,Ruth Chia,Kelechi Ndukwe,J. Ding,Mike A. Nalls,Maciej B. Olszewski,David N. Hauser,Ravindran Kumaran,Andres M. Lozano,Veerle Baekelandt,Lois E. Greene,Jean-Marc Taymans,Elisa Greggio,M. R. Cookson,Vincent Plagnol,Maria Martinez,Dena G. Hernandez,Dena G. Hernandez,Manu Sharma,UM Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,S. Sveinbjornsdottir,S. Sveinbjornsdottir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Jose Bras,Kathrin Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Sean Chong,Carl E Clarke,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,Omar Gustafsson,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,H. Z. Munchen,Palmi V. Jonsson,Jean-Charles Lambert,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,Olaf Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,Chris C. A. Spencer,Hreinn Stefansson,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Nigel Williams,Caroline H. Williams-Gray,Sophie Winder-Rhodes,Kari Stefansson,John Hardy,Peter Heutink,Alexis Brice,T. Gasser,T. Gasser,Andrew B. Singleton,Nicholas W. Wood,Patrick F. Chinnery,Luigi Ferrucci,Robert L. Johnson,Dan L. Longo,Elisa Majounie,Richard O'Brien,Juan C. Troncoso,M. Van Der Brug,H. R. Zielke,H. R. Zielke,Alan B. Zonderman +168 more
TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.
Journal ArticleDOI
Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort.
Sophie Winder-Rhodes,Jonathan R. Evans,Maria Ban,Sarah L Mason,Caroline H. Williams-Gray,Thomas Foltynie,Raquel Duran,Niccolo E. Mencacci,Stephen Sawcer,Roger A. Barker +9 more
TL;DR: It is shown that in a representative, unselected UK Parkinson's disease population, GBA mutations are present at a frequency of 3.5%.
Journal ArticleDOI
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Ganqiang Liu,Brendon P. Boot,Brendon P. Boot,Joseph J. Locascio,Joseph J. Locascio,Iris E. Jansen,Iris E. Jansen,Sophie Winder-Rhodes,Shirley Eberly,Alexis Elbaz,Alexis Brice,Bernard Ravina,Jacobus J. van Hilten,Florence Cormier-Dequaire,Jean-Christophe Corvol,Roger A. Barker,Peter Heutink,Peter Heutink,Johan Marinus,Caroline H. Williams-Gray,Clemens R. Scherzer +20 more
TL;DR: It is hypothesized that specific mutations in the β‐glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease patients, whereas non‐neuropathic GD mutations confer intermediate progression rates.
Journal ArticleDOI
Translational Approaches to Frontostriatal Dysfunction in Attention-Deficit/Hyperactivity Disorder Using a Computerized Neuropsychological Battery
Samuel R. Chamberlain,Trevor W. Robbins,Sophie Winder-Rhodes,Ulrich Müller,Barbara J. Sahakian,Andrew D. Blackwell,Jennifer H. Barnett +6 more
TL;DR: Substantial cognitive deficits are present in ADHD, which can be remediated somewhat with current medications and which can readily be modeled in experimental animals using back-translational methodology.