Journal ArticleDOI
Nickel-Catalyzed Cyclizations, Couplings, and Cycloadditions Involving Three Reactive Components
TLDR
This account outlines work primarily from the author's laboratory on the development of nickel-catalyzed multicomponent coupling processes, an overview of new synthetic methods, a discussion of potential mechanisms, and a description of applications in complex-molecule synthesis are provided.Abstract:
Transition-metal-catalyzed processes that allow the efficient coupling of three reactive components in a chemoselective and stereoselective fashion are particularly useful in the synthesis of complex organic molecules from simple, readily available substrates. This account outlines work primarily from the author's laboratory on the development of nickel-catalyzed multicomponent coupling processes. An overview of new synthetic methods, a discussion of potential mechanisms, and a description of applications in complex-molecule synthesis are provided.read more
Citations
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Journal ArticleDOI
Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
Journal ArticleDOI
Recent Applications of Palladium-Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries
TL;DR: In this review different examples from 2001-2008 are highlighted, which have been performed at least on a kilogram scale in the chemical and pharmaceutical industries.
Journal ArticleDOI
Cycloisomerization of 1,n-enynes: challenging metal-catalyzed rearrangements and mechanistic insights.
TL;DR: This Review aims to highlight the main contributions in this field of catalysis and to propose and comment on the mechanistic insights of the recent discoveries.
Journal ArticleDOI
Accurate reaction paths using a Hessian based predictor–corrector integrator
TL;DR: A new integrator for the steepest descent pathway is presented, a Hessian based predictor-corrector algorithm that affords pathways comparable to the previous fourth order method at the cost of a second order approach.
References
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Cyclic carbopalladation. a versatile synthetic methodology for the construction of cyclic organic compounds
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A New Stereoselective Method for the Preparation of Allylic Alcohols
Eric Oblinger,John Montgomery +1 more
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New Efficient Nickel-Catalyzed Cross-Coupling Reaction between Two Csp3 Centers
TL;DR: Results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)(2) as a catalyst leading to a broad range of polyfunctional cross-Coupling products.
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Tandem Use of Cobalt-Mediated Reactions to Synthesize (+)-Epoxydictymene, a Diterpene Containing a Trans-Fused 5−5 Ring System
TL;DR: The diterpene (+)-epoxydictymene has been synthesized in 20 steps using the asymmetry of (R)-pulegone and several substrate-controlled diastereoselective reactions to prepare the natural product in its natural configuration.
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Total synthesis of mycophenolic acid
TL;DR: Synthese a partir de t-butyldimethylsiloxy-8 (=R-8) methoxy-1 methyl-5 octene-4yne-1 et de methoxymethoxymethyl-3 (=R'-3) methyl-2 cyclobutene-2one-1 via la cyclisation de l'acide R-3 R'-6 hydroxy-2 methoxy -4 methyl -5 benzoique as mentioned in this paper.