Journal ArticleDOI
Nicotinic Acid Benzylidene/Phenyl-Ethylidene Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Studies
Rakesh Narang,Balasubramanian Narasimhan,Sunil Sharma,Dharmarajan Sriram,Perumal Yogeeswari,Erik De Clercq,Christophe Pannecouque,Jan Balzarini +7 more
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This article is published in Letters in Drug Design & Discovery.The article was published on 2011-09-30. It has received 18 citations till now.read more
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Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents
TL;DR: The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents.
Journal ArticleDOI
Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones
Sumit Sigroha,Balasubramanian Narasimhan,Pradeep Kumar,Anurag Khatkar,Kalavathy Ramasamy,Vasudevan Mani,Rakesh Kumar Mishra,Abu Bakar Abdul Majeed +7 more
TL;DR: The quantitative structure activity relationship studies indicated the importance of topological parameter, valence first order molecular connectivity index in describing antifungal activity, but the developed QSAR models were statistically insignificant with reference to anticancer activity of the synthesized compounds.
Journal ArticleDOI
Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives
Tiago Fernandes da Silva,Walfrido Bispo Júnior,Magna Suzana Alexandre-Moreira,Fanny N. Costa,Carlos Eduardo da Silva Monteiro,Fabio Furlan Ferreira,Regina C. Barroso,François Noël,Roberto T. Sudo,Gisele Zapata-Sudo,Lídia Moreira Lima,Eliezer J. Barreiro +11 more
TL;DR: Compounds 10–26 and their conformationally restricted analogue 9 showed great anti-inflammatory and/or analgesic activities, but compound 13 stood out as a new prototype to treat acute and chronic painful states due to its important analgesic activity in a neuropathic pain model.
Journal ArticleDOI
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
Kateřina Hrušková,Eliška Potůčková,Tereza Hergeselová,Lucie Liptáková,Pavlína Hašková,Panagiotis Mingas,Petra Kovaříková,Tomáš Šimůnek,Kateřina Vávrová +8 more
TL;DR: Ten analogs of methyl- and ethyl-substituted SIH derivatives with modified hydrazide scaffolds were synthesized and new structure-activity relationships among antiproliferative and antioxidant aroylhydrazones were highlighted and new lead compounds for further development were identified.
Journal ArticleDOI
Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents
Preeti Arora,Rakesh Narang,Sonam Bhatia,Surendra Kumar Nayak,Sachin Kumar Singh,Balasubramanian Narasimhan +5 more
TL;DR: In present study a series of 2,4-disubstituted thiazole derivatives was synthesized and evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S. aureus and A. niger by tube dilution method.