Nitric Oxide and Redox Regulation in the Liver: Part II Redox biology in Pathologic Hepatocytes and Implications for intervention
Diana L. Diesen,Paul C. Kuo +1 more
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TLDR
In this paper, the authors discuss basic redox biology in the liver, including a review of reactive oxygen species, reactive nitrogen species, and antioxidants, with a focus on nitric oxide as a common source of RNS.About:
This article is published in Journal of Surgical Research.The article was published on 2011-05-01 and is currently open access. It has received 63 citations till now. The article focuses on the topics: Oxidative stress & Reperfusion injury.read more
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The role of antioxidants in the chemistry of oxidative stress: A review.
TL;DR: This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on the ability of antioxidants (of different structures and sources, and following different mechanisms of action) in fighting against oxidative stress.
Journal ArticleDOI
Oxidative stress as a crucial factor in liver diseases.
TL;DR: Monitoring oxidative markers among hepatocytes offers the potential to diagnose the degree of liver damage and ultimately to observe the response to pharmacological therapies, as well as explaining the pathogenesis of various liver disorders.
Journal ArticleDOI
Oxidative stress and human health
TL;DR: A gross picture is generated on the critical role of ROS in deteriorating human health and the importance of antioxidative defense system in ameliorating the toxicity of ROS is generated.
Journal ArticleDOI
Nitric oxide in liver diseases
Yasuko Iwakiri,Moon Young Kim +1 more
TL;DR: Two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - are presented and suggestions for future directions in NO-related studies on the liver are suggested.
Journal ArticleDOI
Oxidative stress and liver disease
TL;DR: This review summarizes the biological character of free radicals and some antioxidants, and the related methods of analysis, and discusses the association of oxidative stress to many types of liver diseases.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
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Oxygen-derived free radicals in postischemic tissue injury.
TL;DR: It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
Journal ArticleDOI
Tissue Destruction by Neutrophils
TL;DR: With increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndromes, blistering skin disorders, and ulcerative colitis.
Journal ArticleDOI
Nitric oxide: an endogenous modulator of leukocyte adhesion.
P Kubes,M Suzuki,D. N. Granger +2 more
TL;DR: Data suggest that endothelium-derived NO may be an important endogenous modulator of leukocyte adherence and that impairment of NO production results in a pattern ofLeukocyte adhesion and emigration that is characteristic of acute inflammation.
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Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Edgar R. Miller,Roberto Pastor-Barriuso,Darshan Dalal,Rudolph A. Riemersma,Lawrence J. Appel,Eliseo Guallar +5 more
TL;DR: This meta-analysis of 19 randomized, controlled trials involving more than 135000 participants found that high-dosage vitamin E supplementation (400 IU/d for at least 1 year) increased all-cause mortality.
Related Papers (5)
Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis.
Diana L. Diesen,Paul C. Kuo +1 more